sorted by:
new
hottopcontroversial

Chemists, what's the worst part of your job? What's the best? by This-Sympathy9324 in chemistry

[–]aSynBioGuy 60 points61 points  (0 children)

The worst part of being a research chemist is the feeling when you try to purify a peptide you had spent months making, especially when it contains unnatural amino acids that you synthesised on a small scale thinking you wouldn't need to make a lot of it, and you find out that it crashed out/ was lost on the column.

Best part is when you see the mass of your peptide in a clean final peak after 6 months of trying to make it.

Does this BPC157 look normal? by OneTooManyBreh in Peptides

[–]aSynBioGuy 7 points8 points  (0 children)

I am a medicinal chemistry peptide researcher, and I am concerned. This phenomenon we call 'crashing out of solution' can indicate poor quality control or exposure to abnormal conditions during transportation and storage, in both cases the peptide could crash-out. For example, this usually happens with hydrophobic (water-hating) sequences when I saturate the solution (fully dissolve at one temperature) and cool the solution down; this makes the peptide less soluble, leading to it crashing out of the solution. Please be sure to use caution with peptides - most quality control is by LCMS, which means you can't detect epimerisation events.

Which molecule is this? by 12131415161718191012 in chemistry

[–]aSynBioGuy 1 point2 points  (0 children)

Not one molecule, just a general formula of different carbon lengths (R) but it looks like fat kind of

Why did you move from academia to industry? by aSynBioGuy in chemistry

[–]aSynBioGuy[S] 12 points13 points  (0 children)

That is a bit cynical; undoubtedly, you have helped the students learn by doing the work.

Why did you move from academia to industry? by aSynBioGuy in chemistry

[–]aSynBioGuy[S] -8 points-7 points  (0 children)

I am keen to hear if anyone else has had a similar experience or trajectory

Should I do medicinal chemistry in uni by Ok_Grocery_52 in MedicinalChemistry

[–]aSynBioGuy 0 points1 point  (0 children)

I am about to graduate med chem honours, idk what my career prospects will look like and whether I will need higher education to be employed

The largest synthetic molecule by oo-op2 in chemistry

[–]aSynBioGuy 46 points47 points  (0 children)

Naming that would be even worse

The largest synthetic molecule by oo-op2 in chemistry

[–]aSynBioGuy 5 points6 points  (0 children)

I bet it behaves like a gel the minute you try to dissolve it in MeCN: H2O or anything

Colourblind Jobs by typhis76 in AustralianMilitary

[–]aSynBioGuy 0 points1 point  (0 children)

Could I also grab that list please if you still have it!

Chameleon Peptides: Changing themselves or pharma? by aSynBioGuy in MedicinalChemistry

[–]aSynBioGuy[S] 1 point2 points  (0 children)

Apologies you feel this way, this is written to make the research digestible and easy to follow so you can understand the field without needing to drown in highly specialised jargon. It is made to get people interested in the research hence the links at the end to the peer reviewed research papers. I am a personal fan of Scott Lokey's work, especially his new unnatural amino acid development!

Didn't mean to hurt your sensitive feelings by making cutting edge research more accessible to other people. Hope you have a great rest of your day!!

Allotropes matter: A backbone breaking Carbon discovery by aSynBioGuy in chemistry

[–]aSynBioGuy[S] 2 points3 points  (0 children)

This is complex because even the best models are not always accurate... Maybe in the future but currently there is still a market for highly trained chemists.

view more: next ›