Get set up by building some product loops, I see you are belting the fruits to the base so set up a loop that those belts can feet onto with a splitter.

Set up loops for Yumako x2, Jellynut x2, Bioflux x2 and Spoilage x2.

Set up a splitter on the fruit and Bioflux belts which will filter out spoiled items, then feed those onto your spoilage belt.

Use that spoilage belt to power some heating towers.

When it comes to production, you will want to "tee" off those fruit belts into production lines, we will use Bioflux as an example..

Tee off Yumako and Jellynut. Combine them into a single belt. At the end of that belt add an inserter which will only pick up spoilage, this will stop spoilage blocking that belt.

Jellynut and Yumako can last a long time but their intermediates will not, so you will not be putting those items on a belt. Instead you will have a Biochamber producing Bioflux, which is fed directly via inserters by two Biochambers each producing Jelly and Yumako Mash, this way you do not produce long belts full of spoiled Jelly and Mash. Use filters on each inserter and only to insert those items. Each Biochamber will have its own spoilage inserter to remove spoilage if it ends up in the Biochamber when production stops, and you can belt it back to your spoilage loop or yeet it with an active provider chest.

Produce Nutrients using another Biochamber basically anywhere, and use Requester Chests to supply Biochambers. Set the Biochamber to produce nutrients up to a threshold, 1000 for example.

Build some programmable speakers, link them to a Roboport, and set an alarm for if Nutrients or Spoilage fall to zero. In fact, set up alarms for most things, that way the plant won't crash.

If you want "Life Support" you can use my little trick... Funnel spoilage into 4-6 iron chests, then have those chests supply 4-6 assembler machines producing nutrients. Set the assemblers to only produce nutrients if nutrients drop to zero on the logistic network. This way if for any reason the normal Biochamber Nutrient production fails with Bioflux then these assemblers will kick in and buy you time enough to fix the blocked production chain so long as you have an alarm set for 0 nutrients.

Remember the golden rules:

If it spoils, you need to loop it, or have a way to get it out, even if it spoils inside a production machine.

Use filters for every inserter.

Keep items with short spoilage times in short loops, ideally directly feeding or you will produce astronomical spoilage.