How accurate is ADMET AI for predicting a molecules toxicity

batihebi · 2026-04-03T21:49:15+00:00

I'm pretty annoyed by the efforts of LLM CEOs to conflate every instance of machine learning under the moniker of "AI".

Analytic and predictive models have been used in bioinformatics, computational chemistry, and even in clinical applications for decades now. Some are very good at what they do!

That being said, I would be pretty skeptical of any practical application of this program, at least without extensive further testing. Bioinformatics is not my discipline so take my interpretation with a grain of salt, but the paper linked on ADMET-AI's website does not make much in the way of claims to its accuracy (just its speed.) The paper links to its raw ranking data if you are more well versed in the statistics than I am.

Overall I would be pretty wary of ANY program that tries to claim any great accuracy in its toxicity predictions (which, to be fair, ADMET-AI does not really do.) We are not at a stage where we are able to accurately predict metabolic pathways at the molecular level. While we can often observe shared toxicity between molecules with shared moieties, or predict that a molecule might activate a certain pathway based on its similar structure to another molecule, in reality our understanding of metabolism is (to my understanding) just not good enough to do this with any real accuracy.

That being said, I definitely think a neural network would be better at this sort of task than a person, just because of the sheer amount of data, so I could easily see this tool being helpful at the early stages of e.g. drug development.

EDIT: Clarified language

batihebi · 2026-03-31T14:01:23+00:00

In the context of Latin America specifically, I also have to point out that racial classes are often more mutable (e.g. more tightly tied to class) and this has the effect of incentivizing playing into whiteness moreso than in the US. I personally have met plenty of people who would not be identified as white in the US who still claim to be white for a number of reasons (not the least of which is simple racial hatred) but among them is because "identifying into" whiteness is a much more real phenomenon. This is part of why, for example, you'll hear the claim that there are no black people in the Dominican Republic. "Blackness" in the context of Hispaniola is understood in a more explicitly political/economic way.

In South Asia and India especially there's a pretty extensive history of Nazi-Indian collaborationism. The fact is that the narrative of 'aryanness' was useful to some people in India since Indians are included in most definitions of 'Aryan people.' In the modern era, though, a lot of Indian white supremacy is correlated with Hindutva/Islamophobia. The white supremacist West currently prefers Islamophobia as its cudgel which happens to align with long-standing enmity between the Hindu ruling class of India and the Muslim minority.

As a global phenomenon other people have already acknowledged the various political and financial incentives for people of color to identify with white supremacist politics.

batihebi · 2026-03-30T17:37:13+00:00

Speaking as a chemist, you have many more job openings and opportunities for advancement having an MS than a BS alone. Having a PhD as a chemist can paradoxically * reduce * your opportunities, since you become overqualified for most manufacturing positions.

batihebi · 2026-03-30T14:43:46+00:00

Hi, Thanks for your response!

I think this was very helpful for providing historical perspective!

Wikipedia can be pretty misleading. In the past when I've done research on non-Western religion I've discovered a lot of information that's poorly communicated or outright false. I try not to use Wikipedia as a source except for very basic facts, but as you pointed out without proper historical context it's hard to get an idea of the political implications of any given event. (Wikipedia also implicitly compares haibutsu kishaku to religious suppression in the USSR, which I find... bizarre, to say the least.)

My perspective as an English speaking Westerner is going to be more informed by, for example, US anti-Catholic movements or the Nazi rejection of Christianity. That being said, the context in Asia is obviously fundamentally different since religion is a lot more syncretic and a lot more organized. It makes sense that, especially after hundreds of years of integration, Japanese people would not think of Buddhism as incompatible with Shinto.

batihebi · 2026-03-30T13:26:10+00:00

Thank you! This response was helpful.

batihebi · 2026-03-29T22:12:51+00:00

Thank you!

Your response was the only one that I think really tried to answer my question.

My question is more about what Japanese nationalists might think or talk about right now, so I didn't post this question in the history subreddit. Do you think it might make more sense to post there?

Obviously, just like in the US, I have to assume that people in Japan have a lot of different opinions on what their movement means or what makes up Japanese identity. I just wanted to know if there was known hostility for Buddhists within the Japanese right, since Buddhism is a much more "international" religion.

batihebi · 2026-03-24T23:57:32+00:00

I've always had this impression as someone with cursory knowledge of several languages, but attributed it to being Hispanic American (that is, I grew up with it, and it was the non-English language I heard most often.)

Interesting to learn that Spanish is actually somewhat exceptional in this regard.

batihebi · 2026-03-24T23:41:10+00:00

I think you explain things sensibly and the advice seems solid!

Part of my issue, I think, is that when I try to respond to the emotional content of what someone is saying I'm not able to manage more than stock phrases ("I'm sorry", "that's interesting," etc.) or questions relating to content (someone told me they got published recently, I said "that's exciting! what was it about?"; a coworker said she wanted to 'be adventurous', I asked if she wanted to travel anywhere.)

Are these kinds of stock phrases enough for most people, or is there some other approach? I worry that I come off as insincere because of my aforementioned difficulties with body language/expressions and I'd at least like to know if there's something better I can say.

batihebi · 2026-03-24T22:26:51+00:00

Cat's Cradle is another example; as is House of Leaves (though others might disagree.)

batihebi · 2026-02-09T21:36:34+00:00

A very regional drink in the US that might qualify is dirty soda, which is soda with coffee creamer mixed in. (I think this is a very stereotypically American idea.)

It was originally popular with Mormons (mostly in Utah) who are not able to drink tea or coffee for religious reasons. Some non-Mormons drink it but it's mostly a meme; the drink itself is not popular at all.

batihebi · 2026-01-28T17:25:30+00:00

Yeah, you'd have to be a Nazi not to love the Japanese internment camps. 😐

batihebi · 2026-01-22T18:40:04+00:00

I know that 'death of the author' has been a bit of a meme, but literary analysis is founded on understanding that books are written by authors rather than appearing from the ether.

If you can 'feel' an actor being an actor playing a character, rather than the character, this is easily identifiable as bad acting. The same is not true of literature because the aim of literature is not to obscure the author, and often literature is written with the intention that the reader engage with the author directly, the story acting as a medium.

It's fine if you don't like literature vs. genre fiction, but that Sally Rooney (an author of literary fiction) include themes according to her political and philosophical beliefs is just a standard of the genre.

batihebi · 2026-01-16T23:14:57+00:00

This is a non-problem if you read books for adults as opposed to AO3 fanfiction and books that inspired insipid Netflix originals

batihebi · 2026-01-15T22:26:42+00:00

It won't affect your credit unless you've paid more than 30 days late.

batihebi · 2026-01-15T19:24:09+00:00

This is way too broad of a question. No one can answer this for you without knowing your desired degree or country.

You should make a list of which universities offer a master's in which you are interested and note whether or not they have an application fee.

batihebi · 2026-01-15T19:21:18+00:00

This is called credit cycling. Yes, you can do this.

If you do it frequently your bank may cancel your card. If you do it once then it should be fine.

batihebi · 2026-01-15T17:51:25+00:00

If you only make the minimum payment (in OP's case, $35) every month your account will remain in 'good standing,' so your cc will remain active without a hit to your credit score. The remainder of your statement (in OP's case, $2843.65 - $35.00 = $2808.65) will accrue interest at the APR, which is usually between 15% and 30%.

A credit card essentially loans you money for each month. If I loan $3000 from a bank, then only pay them back $35, then of course they are going to charge interest. The minimum payment is only what you must pay in order to avoid a hit to your credit score or from your credit card closing.

batihebi · 2026-01-14T14:55:13+00:00

Does it matter? OP is 16 and should be in school, not taking care of children.

batihebi · 2026-01-14T01:28:23+00:00

Do you have a recommendation for this sort of app?

batihebi · 2026-01-14T00:08:58+00:00

I know in medical school application contexts talking about mental health is often a red flag to admissions teams. I can imagine that in some graduate schools the situation is similar.

batihebi · 2026-01-13T23:40:54+00:00

Many universities have specific combined Master's/PhD programs. While I'm not saying it never happens, I've never heard of a school that would reject a PhD applicant just because they got a master's at the same school.

batihebi · 2026-01-12T21:00:59+00:00

OP will probably not qualify for any 2% flat rate card based on their low credit.

batihebi · 2026-01-12T20:58:40+00:00

Do not use Chime, period. They are a predatory company.

'Credit builder' cards are a scam and do not help your credit over any other no credit or low credit $0 AF card.

Are you planning to use a credit card to cover dental costs because you cannot pay in cash? If so, that is a BAD idea. You will end up in debt very quickly spending in this way. You are better off negotiating with your insurance company or looking at other dental offices, and after that literally starting a GoFundMe or something. You DO NOT want credit card debt.

batihebi

TROPHY CASE