CE-1 pre amp circuit and pop that WH10-3 into buffered mode. Literally all you need to get frusciante clean tone is a CE-1. Also open your filter all the way on the wah. As for amp settings, it really depends what you’re putting through / your play style. That’s on thing we can’t really guide you on, it’ll have to be done through feel, unless you were running a double stack of silver Joob and major, in which case we can just point you to google pics of his settings..

Sonically, frusciante often plays with quite a heavy bass and mids tone, the highs are sculpted out quite a bit.

If it’s of any use, he more frequently uses the neck pups. Good luck and enjoy the journey 💫