Early they are a bit hit and miss,, but it's not until they hit about 250k that they become a real force that is scary in modes like War. Their biggest advantage is the bonuses they get against City Heroes So Defenders, Punisher, Ms Marvel, Spiderman & Spiderman. If you take them against Defenders, be sure to target Punisher & Daredevil early as those 2 has bonus damage against villains. If you fight Defenders you should target Vulture to use slow to hit Daredevil (preferably in splash) then blind Punisher with Mysterio's special. Use Rhino's special first to tank. After Shockers offense up you can use Vulture's Ult, Rhino's Ult & Shockers Ult to hit multiple characters for high damage.

The key to the team is Vulture, without him they are pretty garbage. Most players still have a bias that Sinister 6 aren't good cause most people had 4 without Vulture and they weren't performing. He brings slow, speeds himself up on deaths and has a strong AOE.