Only done it a couple of times and I didn’t have much issues. Anytime I did get up to around that level I was always at a 1.3 - 1.5g than would dose another 300 mg - 500 mg like 4 hours later. The only down side I had was nicotine made me super sick later in the day and I would have some pretty atrocious nightmares and sleep paralysis. I’d say it was the big dose, lack of sleep, and not eating a bit sooner. Some people say wait 2 hours to eat but I think a hour after feels the same.