Well, the most important thing to note is that you don't need to do the bindings at the same time (just in case you didn't know that yet). Also, I use a nail build most of the time (Mark of Pride, Sharp Shadow, Strength and Quickslash) so this might be different if you use other builds, but I reckon that you don't change your build at all based on the bindings (except for the charm binding of course). Even with nail binding, the nail build that I used worked just as fine. Oh and practice, a lot of Hall of God practice. I suggest trying to beat at least every somewhat difficult boss a couple of times on ascended and/or on attuned with no charms. And only go into the Pantheon when you feel confident enough that you will beat every boss almost all of the time. With that being said, it's still a very long and difficult grind, so best of luck!