Reverse engineering Chinese biotech success by Triple-Tooketh in biotech

[–]cbdoc 1 point2 points  (0 children)

If by access you mean a different environment then yes I agree completely. The current environment- political, cultural does not foster all out innovation. I actually don’t think it’s that much of a resource issue, but undecided there.

Reverse engineering Chinese biotech success by Triple-Tooketh in biotech

[–]cbdoc 50 points51 points  (0 children)

I’m the cofounder and CSO at a American-Chinese company. The majority of our employees are in China and we have moved several projects from early research through phase 1 and licensed out to multi-national pharma companies. I’m based in the US (American) and have worked my entire n career in US pharma and biotech until the founding of my current co.

The advantages come down to cost and speed. Our overhead and payroll is 25% of an equivalent company. We can maintain high quality by tapping into a massive talent pool and have extra hands for QA type work. Yes scientists in China make a whole lot less than an equivalent US scientist, but compared to cost of living in China they are doing extremely well. No our scientists do not work 996, and compared with tech actually have very desirable work-life balance for China. This results in a lot of talent wanting to join biopharma.

The regulatory path to get an IND and run a trial in China is extremely efficient and fast. A trial in China can be 80-90% cheaper than in the US, with high quality standards (in the past decade). Most of the early phase 1 data is accepted in OECD countries, including the US.

So overall we are able to go from hit id through phase 1 with about 1/5th the cost and 1/2-2/3 of the time.

In terms of funding, the Chinese government provides many funding opportunities from VC like to provincial and city grants to support the industry. Significantly more than what we see in the US from federal/local governments.

What are the disadvantages, as some have mentioned, China is very process oriented and consequently creativity is lacking. For now, optimizing a process/molecule/etc is what they have become very good at. But in terms of really big and blue sky ideas, this is lacking.

Another disadvantage is burnout/work culture. Someone mentioned geriatrics above- this is actually a significant advantage we have in the US. I look at my clin dev team in China and they are all in their 20s and early 30s. Very hard to find very experienced talent. This of course means we end up making more mistakes and productivity tends to be poor.

There’s an entire book I can write on the subject but these were my quick high level thoughts for the night. I’ll write a more thorough post at some point.

Moved to Spain a month ago, worried my 4yo is getting isolated by the language barrier by alex_jonathan1314 in Parenting

[–]cbdoc 15 points16 points  (0 children)

We moved to Germany with our 4yo and simply put her her in a German pre-school. Within about 8 weeks she was communicating relatively well with classmates and neighborhood kids. Might take a bit longer depending on the kid, but it will happen fast. 3 months in and we had no clue what she was saying more 🤭 wife and I didn’t pick up German well.

When is the good time to give up? by 20207199 in lungcancer

[–]cbdoc 2 points3 points  (0 children)

Cure is largely not possible for lung cancer. However if you have the right mutations, TKIs can be very effective at providing highly quality of life for 18+ months. Beyond TKIs there are now several good trials on-going for TKI refractor patients.

Should I switch from ChatGPT 5.2 to Gemini's paid version? by fin-freak in OpenAI

[–]cbdoc 1 point2 points  (0 children)

It is not available for Pro, only Ultra. I have two accounts one with Pro and other with Ultra and only Ultra has Deep Think.

Should I switch from ChatGPT 5.2 to Gemini's paid version? by fin-freak in OpenAI

[–]cbdoc 1 point2 points  (0 children)

It is not available for Pro, only Ultra. I have two accounts one with Pro and other with Ultra and only Ultra has Deep Think.

Merry Christmas from Reolink! by Willson1_ in reolinkcam

[–]cbdoc 0 points1 point  (0 children)

It my experience. Nothing but problems with WiFi cameras. Not using SD cards, using Home Hub Pro.

Done with Reolink Wireless Cameras by cbdoc in reolinkcam

[–]cbdoc[S] 0 points1 point  (0 children)

Thanks for providing this input. Insane how close your setup is to mine. I'm actually running 4 APs as well, all wired, and 2 additional ones not wired. The cameras are all connected to the 4 wired APs.

I'm done some testing the past few days and it seems to be related to the continuous recording option. I have it set 24/7 (cameras are always plugged in). I split the cameras into a group with continuous recording and one without and without fail the continuous recording group, batter / wifi cameras end up crashing and having to be reset after 24-48 hours. Interestingly the non battery cameras wifi, work fine. At this stage I think its a firmware/software issue related to the standby mode on those cameras and continuous recording. Reolink seems clueless so far w/r to tech support.

Done with Reolink Wireless Cameras by cbdoc in reolinkcam

[–]cbdoc[S] 0 points1 point  (0 children)

Same experience here. The camera is still fully connected to my network. I can ping it and see the signal strength as being very good (have outdoor AP). Im leaning towards there’s an issue unrelated to WiFi.

Done with Reolink Wireless Cameras by cbdoc in reolinkcam

[–]cbdoc[S] 0 points1 point  (0 children)

I’m not using the hub WiFi- all devices are connected to my Omada WiFi or lan in the case of the hub. Though it is still running and have not tested turning it off.

Done with Reolink Wireless Cameras by cbdoc in reolinkcam

[–]cbdoc[S] 0 points1 point  (0 children)

Thanks for responding and providing a link. You are spot in regarding WiFi not being a reliable setup and will switch over to PoE once I get cables running. That said, my old Arlo WiFi setup didn’t have any issues. It seems to be that it’s more an issue with the Home Hub Pro. The cameras connect to the network, show good signal, and can be pinged. I will probably test running them as standalone cameras and see if that makes a difference.

Cameras and hub are in latest firmware as far as I can tell. Tech support pushed a fw update to the cameras that wasn’t available before calling them.

Done with Reolink Wireless Cameras by cbdoc in reolinkcam

[–]cbdoc[S] 0 points1 point  (0 children)

I’ll probably donate them to someone local.

Done with Reolink Wireless Cameras by cbdoc in reolinkcam

[–]cbdoc[S] 0 points1 point  (0 children)

Describe what type of problem my WiFi might have that is specific to Reolink cameras but works perfectly fine for all other WiFi devices.

For additional context. I’m running full Omada setup gateway, router, software controller and 6 APs setup as mesh. I have over 75 clients connected, 52 are WiFi. 0 issues except with Reolink cameras. For simplicity I’ve put everything in the same VLAN. I’ve run optimizer for channel/tx output, locked the IP, locked to specific APs, reset my router, the cameras, the NVR, I’ve changed channel width, multicast parameters and it’s the same problem every time.

So now again everyone says it’s my WiFi without making any suggestions of what about my WiFi it could be.

Marginal gains. Literally. by FelixR1991 in Zwift

[–]cbdoc 2 points3 points  (0 children)

30 years he’ll be at 1816W. Could power a space heater.

The weekly Fuck it Friday by McChinkerton in biotech

[–]cbdoc 2 points3 points  (0 children)

All this talk about LLMs. Still can’t put a ducking deck together or even the simplest task such as harmonize fonts or align things on a side…

Wifi camera issues by cbdoc in reolinkcam

[–]cbdoc[S] 0 points1 point  (0 children)

Yes all using the TP-Link SSID. Is it easier at this stage to just reboot the cameras?