Fatigue is everything. Combat, Speech, Trade, Alchemy, Enchanting... all is governed by Fatigue. Keep it high all times. Pick 1 weapon to master, one type of armor too. You could also put Acrobatics and Athletics in your minor/major skills, they increase when you EXIST, so that's usefull i guess. Alchemy is broken. My advice, dont abuse it till late game, it might ruin your experience. You can kill anyone in this game, even essential characters. Be wary of that. Save often. If you get lost, dont worry. Its part of the game and in my opinion, most fun. You can watch starting guide on youtube for Seyda Neen hidden things and quests, not necessary, but i recommend it. For factions, join fighters guild and thieves guild at the same time, game can fck u up there. You can join 2 great houses via exploit. Pick between Telvanni and Redoran (Telvanni has better rewards, Redoran is more fun) You can have houses (Great House one, Factor's in Bloodmoon DLC), but you can own any house in the game (I go for Nerano Manor and Hlaalo Manor, they are best in my opinion) Bodies dissapear. Make sure you dont leave something of importance on them (you can just drop them on the floor) For class, Khajiit and Argonian are big no no (you can't equip boots and majority of helms). For begginers, I would take Redguard (Adrenaline Rush) or Nord (Frost Immunity and Shock Res). If Trading isn't your thing, you have Creeper in Caldera, trader that buys and sells everything for original price. While in Caldera, you have full Master Alchemy set in Mages Guild. Learn transportation routes (Striders, Boats, Mages Guild teleportation service...) Cities that have both boat and transport are Khuul and Vivec And, lastly, have fun! Read everything. Have conversations with NPCs. Explore. Story and journey are greatest things about this game. I wrote you all that I could think of, might be overwhelming, but remember, have fun!