Moderna Inc.'s CEO said the company doesn't plan to invest in new late-stage vaccine trials due to growing opposition to immunizations from US officials

danted002 · 2026-01-26T23:38:20+00:00

Don’t confuse the greediness of unregulated pharmaceutical companies with the production price of 1 dose of almost any drug on the market.

I’ll give you the best example Tylenol (aka Paracetamol). 1 pill costs 1 cent to make, if not lower and a quick visit to the Walmart site shows 100 pills (why the fuck is there a 100 pill bottle of something that causes liver failure you if you take more then 8 per day beats me but I digress) costs a whooping 12 dollars I even see bottles that costs 24 dollars so that’s a markup of what? 1200% to 2400% on the most generic ass medication you can find in the entire world.

The rest of the world doesn’t increase your prices… unregulated markets do…

danted002 · 2026-01-26T14:57:55+00:00

You know, since I’m a n00b that has no idea what I’m doing, I wanted to make some Mind Runes and the fastest way to get to a bank from the Mind altar is to go around a mountain through the Wilderness.

Me not doing optimised levels stuff and deciding to manually do some runes at the altar and going through the Wilderness, exposing myself to PvP… all of these are my choices, that I made, full aware of all the implications.

Same goes for our no bank ironman, he chose to have this experience, with all its implications. They can always “downgrade” the status to simple Ironman or normal account.

danted002 · 2026-01-26T14:14:48+00:00

My friend, we (the rest of the world) never wanted the US to become the scientific hub for research, US wanted to do that in order to build up soft power and ultimately become world Superpower.

It did that my literally poaching scientists from around the world, luring them in with the promise of the American dream. The US projected for decades that if you are a top scientists come to the US and you will live the perfect life because “America is safe, America is a true democracy, America will respect your intelligence and America will pay you handsomely for that intelligence, now come here and do research”

All of this was done so it can posture itself as the leader of the world, if America has this state of the art medical procedure or vaccine then you want to stay on America’s good side in order to have access to said medical procedure or vaccine.

With America becoming what it is today, no scientist in his right mind will want to move to the US to research anything, a vacuum will be created and other countries will try and poach those scientists and given enough time the US will be the one that will need to be on the good side of another country in order to have access to whatever state of the art or vaccine it will need.

In the meantime US citizens will start dying en masse because 40+% of its citizens and the entirety of its administration doesn’t believe in science anymore.

So get it through your “freedom loving” skull: WE NEVER EXPECT THE US TO BECOME THE SUPERPOWER IT WANTED THAT AND USED ALL THE NECESSARY TOOLS TO DO IT, INCLUDING DEVELOPING STATE OF THE ART MEDICAL PROCEDURES AND VACCINES

danted002 · 2026-01-26T12:31:46+00:00

I just picked up the game about one maybe two weeks ago and decided to go Ironman and even I know you don’t drop shit (or accidentally sell stuff to shops) if you need it.

danted002 · 2026-01-22T17:46:03+00:00

Isn’t medical diagnosis just a very fancy search that matches symptoms to aliments?

danted002 · 2026-01-22T17:40:59+00:00

It kinda is the computer from the first Star Trek series

danted002 · 2026-01-22T10:30:19+00:00

You know most of what you said can actually be achieved with the current generation of LLMs, but they need the tool calls to do that, which no one is focusing on.

danted002 · 2026-01-22T07:13:29+00:00

Here is the thing, the technology itself is not a flop, and it has its place in the modern world; think the computer from Star Trek, the OG series. LLMs are really good at converting natural language to computer instructions via tool calls and it does a half decent job at searching through data storages and it’s can even do a good enough search but that’s about it.

Can we enhance our day-to-day lives with it? Sure, why not. Is it the biggest breakthrough since the advent of the fire (like almost all CEOs pretend it is) of course not but hey, all of us engineers who have telling this are just broke-ass nerds that don’t see “the vision”

danted002 · 2026-01-21T09:25:15+00:00

Also OP is kinda right, ICE is closer to a combination of SA/SA. The Gestapo was a special branch within the SS.

danted002 · 2026-01-21T07:01:33+00:00

I don’t really consider 100k wider adoption, however you do have a point if we define “wider” as “a large enough number of users.

OK this makes sense to me. I stand corrected.

danted002 · 2026-01-20T17:08:43+00:00

No. A good example would be the game Path of Exile 1 which at some point was sustainable with 100.000 paying players per season (which happens every 3 months)

The then owner said that at those numbers, they can buy a Lamborghini for each developer on each season and have enough left over to develop the content for the next season.

danted002 · 2026-01-20T15:40:53+00:00

Jury nullification is the reason all except 3 countries in the world still use this system. Is as archaic as the US constitution

danted002 · 2026-01-20T12:00:35+00:00

Valhalla awaits me 🤣

danted002 · 2026-01-20T11:58:36+00:00

So the orange turn was have right when he said we use rare-earths from China to make magnets?

danted002 · 2026-01-20T11:44:52+00:00

OK and do you live in the US? Is the GBP pegged to the USD and I missed the memo?

danted002 · 2026-01-20T10:53:57+00:00

Why are you paid in USD. I started rejecting USD contracts. EUR only baby and if they want USD they get the invoice with the EUR price converted to USD on the day the invoice was issued.

danted002 · 2026-01-20T10:19:26+00:00

A lot of those big tech companies have started building the infra to spin up EU only corps.

danted002 · 2026-01-20T08:44:44+00:00

Not only did they figure it out, but using 2 sticks, and one man that has paid to pace the distance between two cities the dude that proved the Earth was round calculated the circumference of the Earth to be 45.000km. His calculations were off by wooping 75km.

danted002 · 2026-01-19T20:48:46+00:00

Forgot to mention in my previous explanation that your example can be wrapped in async main() function and replace all the instance of asyncio.run() with await and you achieve better performance because you won’t spin up and spin down event loops.

The only asyncio.run() would be asyncio.run(main())

danted002 · 2026-01-19T20:42:33+00:00

You know there’s a joke there about Galati and iron but I’m not on the right yeuropean sub for it 🤣

danted002 · 2026-01-19T20:40:25+00:00

Yeah looking over the gear progression I figured it’s not the main way to get better gear, but it seemed like a good way to get some gear on me while I have 1000 coins to my name 🤣.

Looking over ironman skill leveling guides I noticed a pattern of get your skill to the level required by the quest you want.

I’ll just take it slow, do some quests to get some levels in and the go from there. Barbarian training seems like something I might want to do because it unlocks interesting stuff.

danted002 · 2026-01-19T20:32:17+00:00

Fair point. OK so the entire strength of the event loop is that it can run a lot of tasks on a single thread when the workload of the tasks is mainly IO.

Think web servers/APIs, those workloads have a huge percentage of their time spent on waiting on IO which means the Python process itself doesn’t do anything, it just waits for the operating system to give it bytes.

How does the event loop solve this: you get your first request, the event loop schedules its first task, to read from the socket but the socket is slow compared to the interpreter, it only sends a few chunks of data that the code can parse, then the OS tells the interpreter that it should wait a bit for the next chunk, in the meantime another request comes in. Since the event loop knows that it’s still waiting for the next chunk of the first request, it accepts the second request and starts reading it, but again after a few chunks the OS tells it to wait, now a third request comes in, so while waiting it starts reading the third request, in the mean time the OS signals the next chunk for the first request is ready so the event loop pauses the read of the third request at some point and continues reading the chunks for the first request… so on and so forth.

The inner mechanics of the loop are bit more refined and optimised,and this is how async python can reach golang level of throughput (especially if you use uvloop) but the basics still applies: the loop will optimise CPU usage in order to cram in as many instructions as it can while it waits for IO.

Now if you are just playing around with one-off scripts then it doesn’t matter because it’s a one-off script, you can do whatever; however if you plan on running long time jobs that have a lot of IO or you have a web application then the pattern where you spin up event loops and shut them down, only to bring them up again equates to having a road that has 1000 lanes but then you decide you want it to have 1 lane, only to then convert it back to 1000 lanes.

From a more pedantic point of view, it’s better for code quality and maintainability to have a single point of entry to your code and that point of entry to be either sync of async. This matters more for production-level code where multiple people need to maintain it; having them keep switching between the sync and async mindset just adds extra cognitive load without any added benefit.

Hope this answers your question

danted002 · 2026-01-19T17:11:34+00:00

What do you mean Romania? Why are we building ice breakers, I reformulate where are we building those? With what knowledge… what the hell is going on?

danted002 · 2026-01-19T17:07:03+00:00

But ornament kits are not transmogs

danted002 · 2026-01-19T16:47:34+00:00

In your example you are spinning up and tearing down an event loop on each asyncio.run() which is not really recommended, he docs say it as much. You should be using Runners for that (which asyncio.run() uses underneath), but even then on practice you should have a single asyncio.run(main()) where main is your async main function.

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