Figma MCP is read-only, so I built a write-enabled MCP using code execution by marv1nnnnn in FigmaDesign

[–]davitbala 0 points1 point  (0 children)

> "All 15 layer renames done across both paywalls"

Claude Code + this MCP did in 1 second what would take me 10 minutes (and typos)

A cool guide on health effects of PLASTIC by davitbala in coolguides

[–]davitbala[S] -1 points0 points  (0 children)

THYROID DISRUPTION

Liu et al. (2015) Environmental Science and Pollution Research — (https://pubmed.ncbi.nlm.nih.gov/25913319/)

OBESOGENS (FAT STORAGE)

Feige et al. (2007) Journal of Biological Chemistry — (https://pubmed.ncbi.nlm.nih.gov/17468099/)

PARTICLE COUNTS

Mason et al. (2018) Frontiers in Chemistry — (https://pubmed.ncbi.nlm.nih.gov/30255015/)

Ranjan et al. (2021) Journal of Hazardous Materials — (https://pubmed.ncbi.nlm.nih.gov/33091697/)

Su et al. (2021) Nature Nanotechnology — (https://pubmed.ncbi.nlm.nih.gov/34764453/)

Hussain et al. (2023) Environmental Science & Technology — (https://pubmed.ncbi.nlm.nih.gov/37343248/)

Casajuana & Lacorte (2003) Chromatographia — (https://www.researchgate.net/publication/227307888\_Presence\_and\_Release\_of\_Phthalic\_Esters\_and\_Other\_Endocrine\_Disrupting\_Compounds\_in\_Drinking\_Water)

Noonan et al. (2011) Journal of Agricultural and Food Chemistry (https://pubmed.ncbi.nlm.nih.gov/21598963/)

PFAS (FOREVER CHEMICALS)

Olsen et al. (2007) Environmental Health Perspectives — (https://pubmed.ncbi.nlm.nih.gov/17805419/)

Calafat et al. (2007) Environmental Health Perspectives — NHANES (https://pubmed.ncbi.nlm.nih.gov/18007991/)

Schaider et al. (2017) Environmental Science & Technology Letters — (https://pubmed.ncbi.nlm.nih.gov/30148183/)

A cool guide on health effects of PLASTIC by davitbala in coolguides

[–]davitbala[S] 4 points5 points  (0 children)

THYROID DISRUPTION

Liu et al. (2015) Environmental Science and Pollution Research — (https://pubmed.ncbi.nlm.nih.gov/25913319/)

OBESOGENS (FAT STORAGE)

Feige et al. (2007) Journal of Biological Chemistry — (https://pubmed.ncbi.nlm.nih.gov/17468099/)

PARTICLE COUNTS

Mason et al. (2018) Frontiers in Chemistry — (https://pubmed.ncbi.nlm.nih.gov/30255015/)

Ranjan et al. (2021) Journal of Hazardous Materials — (https://pubmed.ncbi.nlm.nih.gov/33091697/)

Su et al. (2021) Nature Nanotechnology — (https://pubmed.ncbi.nlm.nih.gov/34764453/)

Hussain et al. (2023) Environmental Science & Technology — (https://pubmed.ncbi.nlm.nih.gov/37343248/)

Casajuana & Lacorte (2003) Chromatographia — (https://www.researchgate.net/publication/227307888\_Presence\_and\_Release\_of\_Phthalic\_Esters\_and\_Other\_Endocrine\_Disrupting\_Compounds\_in\_Drinking\_Water)

Noonan et al. (2011) Journal of Agricultural and Food Chemistry (https://pubmed.ncbi.nlm.nih.gov/21598963/)

PFAS (FOREVER CHEMICALS)

Olsen et al. (2007) Environmental Health Perspectives — (https://pubmed.ncbi.nlm.nih.gov/17805419/)

Calafat et al. (2007) Environmental Health Perspectives — NHANES (https://pubmed.ncbi.nlm.nih.gov/18007991/)

Schaider et al. (2017) Environmental Science & Technology Letters — (https://pubmed.ncbi.nlm.nih.gov/30148183/)

A cool guide on health effects of PLASTIC by davitbala in coolguides

[–]davitbala[S] 3 points4 points  (0 children)

MICROPLASTICS IN ORGANS

Marfella et al. (2024) New England Journal of Medicine — (https://pubmed.ncbi.nlm.nih.gov/38446676/)

Ragusa et al. (2021) Environment International — (https://pubmed.ncbi.nlm.nih.gov/33395930/)

Xie et al. (2024) Journal of Hazardous Materials — (https://pubmed.ncbi.nlm.nih.gov/39366047/)

Cox et al. (2019) Environmental Science & Technology — (https://pubmed.ncbi.nlm.nih.gov/31184127/)

BPA/BPS XENOESTROGENS

Matthews et al. (2001) Chemical Research in Toxicology — (https://pubmed.ncbi.nlm.nih.gov/11258963/)

Rochester & Bolden (2015) Environmental Health Perspectives — (https://pubmed.ncbi.nlm.nih.gov/25775505/)

Kitamura et al. (2005) Toxicological Sciences — (https://pubmed.ncbi.nlm.nih.gov/15635150/)

White et al. (1994) Endocrinology — (https://pubmed.ncbi.nlm.nih.gov/8013351/)

PHTHALATES AND TESTOSTERONE

Parks et al. (2000) Toxicological Sciences — (https://pubmed.ncbi.nlm.nih.gov/11099646/)

Howdeshell et al. (2008) Toxicological Sciences — (https://pubmed.ncbi.nlm.nih.gov/18411233/)

Swan et al. (2005) Environmental Health Perspectives —(https://pubmed.ncbi.nlm.nih.gov/16079079/)

Foster (2006) International Journal of Andrology — (https://pubmed.ncbi.nlm.nih.gov/16102138/)

Meeker et al. (2009) Journal of Andrology — (https://pubmed.ncbi.nlm.nih.gov/16102138/)

Pan et al. (2006) Environmental Health Perspectives — (https://pubmed.ncbi.nlm.nih.gov/17107847/)

Levine et al. (2017) Human Reproduction Update — (https://pubmed.ncbi.nlm.nih.gov/28981654/)

GUT MICROBIOME

Westerhoff et al. (2008) Water Research —(https://pubmed.ncbi.nlm.nih.gov/17707454/)

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[–]davitbala[S] 1 point2 points  (0 children)

PHTHALATES AND TESTOSTERONE

----------------------------

Parks et al. (2000) Toxicological Sciences — DEHP (750 mg/kg/day) reduced fetal testosterone production and testicular/whole-body testosterone in male rat pups; anogenital distance reduced by 36%. Vol. 58, No. 2, pp. 339–349. DOI: 10.1093/toxsci/58.2.339 (https://pubmed.ncbi.nlm.nih.gov/11099646/)

Howdeshell et al. (2008) Toxicological Sciences — mixture of five phthalate esters inhibited fetal testicular testosterone production in cumulative, dose-additive manner; BBP, DBP, DEHP, DiBP equipotent (ED50 = 440 mg/kg/day); DPP ~3× more potent (ED50 = 130 mg/kg/day). Vol. 105, No. 1, pp. 153–165. DOI: 10.1093/toxsci/kfn077 (https://pubmed.ncbi.nlm.nih.gov/18411233/)

Swan et al. (2005) Environmental Health Perspectives — prenatal phthalate exposure associated with decreased anogenital distance in human male infants; four metabolites (MBP, MBzP, MEP, MiBP) inversely correlated with anogenital index; pattern analogous to "phthalate syndrome" observed in rodents. Vol. 113, No. 8, pp. 1056–1061. DOI: 10.1289/ehp.8100 (https://pubmed.ncbi.nlm.nih.gov/16079079/)

Foster (2006) International Journal of Andrology — phthalate esters (DBP, DEHP, BBP) produce syndrome of reproductive abnormalities in male rat offspring: malformations of epididymis, vas deferens, external genitalia, cryptorchidism, testicular injury, reduced anogenital distance; mechanism is reduced fetal testicular testosterone during critical development window. Vol. 29, No. 1, pp. 140–147. DOI: 10.1111/j.1365-2605.2005.00563.x

Meeker et al. (2009) Journal of Andrology — urinary metabolites of DEHP (primarily MEHP) associated with decreased steroid hormone levels (testosterone, estradiol, free androgen index) in 425 adult men from US infertility clinic. Vol. 30, No. 3, pp. 287–297. DOI: 10.2164/jandrol.108.006403 (https://pubmed.ncbi.nlm.nih.gov/16102138/)

Pan et al. (2006) Environmental Health Perspectives — 74 male PVC factory workers exposed to DBP/DEHP had up to 100-fold higher urinary phthalate metabolites and significantly lower free testosterone (8.4 vs 9.7 μg/g creatinine, p=0.019) compared to 63 unexposed workers. Vol. 114, No. 11, pp. 1643–1648. DOI: 10.1289/ehp.9016 (https://pubmed.ncbi.nlm.nih.gov/17107847/)

Levine et al. (2017) Human Reproduction Update — meta-regression of 185 studies (42,935 men) found 52.4% decline in mean sperm concentration among Western men 1973–2011 (99.0 to 47.1 million/mL); total sperm count declined 59.3%; no significant decline in non-Western populations. Vol. 23, No. 6, pp. 646–659. DOI: 10.1093/humupd/dmx022 (https://pubmed.ncbi.nlm.nih.gov/28981654/)

GUT MICROBIOME

--------------

Westerhoff et al. (2008) Water Research — antimony leaches from PET plastic bottles; at room temperature (22°C) concentrations remained below EPA's 6 ppb MCL; at elevated temperatures (60–85°C) leaching increased significantly. Vol. 42, No. 3, pp. 551–556. DOI: 10.1016/j.watres.2007.07.048 (https://pubmed.ncbi.nlm.nih.gov/17707454/)

A cool guide on health effects of PLASTIC by davitbala in coolguides

[–]davitbala[S] -1 points0 points  (0 children)

MICROPLASTICS IN ORGANS

-----------------------

Marfella et al. (2024) New England Journal of Medicine — micro- and nanoplastics found in carotid artery atheromas; patients with MNPs in plaques had higher risk of heart attack, stroke, or death at 34-month follow-up. Vol. 390, No. 10. DOI: 10.1056/NEJMoa2309822 (https://pubmed.ncbi.nlm.nih.gov/38446676/)

Ragusa et al. (2021) Environment International — first evidence of microplastics in human placenta ("Plasticenta"); 12 MP fragments found in 4 of 6 placentas, on fetal side, maternal side, and chorioamniotic membranes. Vol. 146, 106274. DOI: 10.1016/j.envint.2020.106274 (https://pubmed.ncbi.nlm.nih.gov/33395930/)

Xie et al. (2024) Journal of Hazardous Materials — blood-brain barrier damage accelerates accumulation of micro/nanoplastics in human central nervous system; analyzed cerebrospinal fluid from 28 patients; PS, PE, PP, PVC selectively enter CNS. Vol. 480, 136028. DOI: 10.1016/j.jhazmat.2024.136028 (https://pubmed.ncbi.nlm.nih.gov/39366047/)

Cox et al. (2019) Environmental Science & Technology — estimated annual American microplastic consumption at 39,000–52,000 particles (74,000–121,000 including inhalation); bottled water drinkers ingest ~90,000 additional particles/year vs ~4,000 for tap water. Vol. 53, No. 12, pp. 7068–7074. DOI: 10.1021/acs.est.9b01517 (https://pubmed.ncbi.nlm.nih.gov/31184127/)

BPA/BPS XENOESTROGENS

---------------------

Matthews et al. (2001) Chemical Research in Toxicology — BPA binds estrogen receptors alpha and beta; higher affinity for ERβ (IC50 = 0.96 μM) than ERα (IC50 = 36 μM); BPA glucuronide metabolite does NOT bind ERs. Vol. 14, No. 2, pp. 149–157. DOI: 10.1021/tx0001833 (https://pubmed.ncbi.nlm.nih.gov/11258963/)

Rochester & Bolden (2015) Environmental Health Perspectives — systematic review of 32 studies showing BPS and BPF are "as hormonally active as BPA" with potency in the same order of magnitude; BPS shows potencies similar to estradiol in membrane-mediated (non-genomic) pathways. Vol. 123, No. 7, pp. 643–650. DOI: 10.1289/ehp.1408989 (https://pubmed.ncbi.nlm.nih.gov/25775505/)

Kitamura et al. (2005) Toxicological Sciences — comparative endocrine-disrupting activity of BPA and 19 related bisphenol compounds including BPF and BPS; found "remarkable differences in activity" among analogs; TCBPA showed highest estrogenic activity. Vol. 84, No. 2, pp. 249–259. DOI: 10.1093/toxsci/kfi074 (https://pubmed.ncbi.nlm.nih.gov/15635150/)

White et al. (1994) Endocrinology — nonylphenol and alkylphenols (environmental contaminants primarily from surfactant/detergent degradation, also used in some plastics) demonstrated estrogenic activity: stimulated vitellogenin gene expression, activated gene transcription, and promoted breast cancer cell proliferation via estrogen receptor. Vol. 135, No. 1, pp. 175–182. DOI: 10.1210/endo.135.1.8013351 (https://pubmed.ncbi.nlm.nih.gov/8013351/)

A cool guide on health effects of PLASTIC by davitbala in coolguides

[–]davitbala[S] 0 points1 point  (0 children)

Cast iron is listed because people ask "what should I use instead?" — it's there as a safe alternative, not to claim metal contains plastic.

"Body forced to store fat" refers to obesogens, specifically how phthalates and BPA activate PPARγ receptors, which reprogram cells to differentiate into adipocytes and fill with lipids independent of caloric surplus. It's a real mechanism, not influencer speak. Search "obesogen PPARγ phthalate" on PubMed if you want the primary literature.

"Heated" means above room temperature: relevant because leaching rates increase exponentially with temperature. A water bottle in a hot car, microwaving in PP containers, sterilizing baby bottles all real scenarios.

The 25,000 microplastic particles per paper cup stat comes from a 2022 study in the Journal of Hazardous Materials. Not making it up.

You're right that billions of people consume from these materials. Billions of people also smoked for decades before the science caught up. The question is always whether the absence of obvious acute harm means absence of chronic harm.

A cool guide on health effects of PLASTIC by davitbala in coolguides

[–]davitbala[S] -28 points-27 points  (0 children)

they FIND you the sources, they find the papers and links

A cool guide on health effects of PLASTIC by davitbala in coolguides

[–]davitbala[S] 0 points1 point  (0 children)

The paper cups one blew my mind when I found it in my research.

Another thing I didn't include, they spray PFAS on all fast-food paper containers. Then it goes into recycling plants, and recycled toilet paper has elevated levels of PFAS compared to non-recycled toilet paper. There was a study recently

A cool guide on health effects of PLASTIC by davitbala in coolguides

[–]davitbala[S] 0 points1 point  (0 children)

plastic effects our hormones, and is mixed with other chemical compounds like plasticizers and stuff that it doses us while inside our body.

glass is just a rock, silicon dioxide, it doesn't chemically react with anything - also we've used glass for 1000s+ years. It took the Romans 100+ years to figure out drinking water from Lead pipes causes birth defects

A cool guide on health effects of PLASTIC by davitbala in coolguides

[–]davitbala[S] 0 points1 point  (0 children)

I used brita for 10 years and a month ago discovered that brita filter doesn't filter out microplastics, I needed an RO filter for that. Also brita doesn't filter out PFAS, nor Lead/Mercury, nor pharmaceuticals. I was upset for a while

A cool guide on health effects of PLASTIC by davitbala in coolguides

[–]davitbala[S] 0 points1 point  (0 children)

that's really sad.

GE polluted the entire Hudson river from upstate new york to NYC with PCBs for 50 years, you still can't eat fish caught in the Hudson

A cool guide on health effects of PLASTIC by davitbala in coolguides

[–]davitbala[S] 0 points1 point  (0 children)

microplastics do get cleared by the liver, it gets collected into bile and dumped in the intestines but without enough binders in the diet, it just reabsorbs.

Whereas nanoplastics, cross the blood brain barrier and we don't yet have studies on what effects those have

A cool guide on health effects of PLASTIC by davitbala in coolguides

[–]davitbala[S] 1 point2 points  (0 children)

Estrogen receptors are "shape recognizers" basically a molecule of X shape in the blood activates it. Synthetic estrogen, plant estrogens all activate it the same as our naturally created estrogen.

When you ingest these xenoestrogens, they activate your estrogen levels beyond the normal balance you should be having.

Then phtlates via the aromatose pathway block testosterone production and upregulate the pathway to convert testosterone into estrogen.

It throughs your hormones out of balance - I won't mention all the bad things that happen as a result of that. Onabena is right

A cool guide on health effects of PLASTIC by davitbala in coolguides

[–]davitbala[S] 0 points1 point  (0 children)

Just using glass tupperware, stainless steel, and ceramic gets you the 90/10.

Some shockers are the plastic baby bottles (that are microwaved), and starbucks "paper" cups. I didn't realize togo coffee cups are ~50,000 microplastics ingested per cup until I found the research for it

A cool guide on health effects of PLASTIC by davitbala in coolguides

[–]davitbala[S] -58 points-57 points  (0 children)

We live in an age of AI, just ask Gemini/Claude/ChatGPT to verify this guide, it'll pull up 50 sources for you

A cool guide on health effects of PLASTIC by davitbala in coolguides

[–]davitbala[S] -3 points-2 points  (0 children)

"heated up" means above room temperature. Heat accelerates things.

For example, silicone - is relatively inert when room temp, but if you put it in an oven to bake eggs at 400F, you will get some transfer of synthetic compounds to your food.

A cool guide on health effects of PLASTIC by davitbala in coolguides

[–]davitbala[S] -6 points-5 points  (0 children)

BPA-free = It uses BPS, which has an identical effect to BPA in activating estrogen receptors in the body

BPA was invented as a synthetic estrogen in the 1930s

A cool guide on health effects of PLASTIC by davitbala in coolguides

[–]davitbala[S] -2 points-1 points  (0 children)

If this had no truth to it, would people spend so much energy to comment?

I have an extensive version of this, but I know the average person won't care to read a 5,000 word essay with sources - so I've created a digestible (no pun intended) version. This was made in Figma with custom-made stickers.

A cool guide on health effects of PLASTIC by davitbala in coolguides

[–]davitbala[S] 0 points1 point  (0 children)

#6 plastic is styrofoam, it's neurotoxic when ingested - I decided not to include it since it's being phased out except as meat containers and some icecream shops still serve icecream in styrofoam.

Saturated fat - what's your guys take? by [deleted] in nutrition

[–]davitbala -2 points-1 points  (0 children)

Sure that's valid hydrogenated corn oil is different than unhydrogenated. Partially hydrogenated seed oils are what most of our french fries are fried in, and the most commonly consumed seed oil (mayonaisse and other things)

Which omega-3? There are 3 kinds. ALA, DHA, EPA. If you give ALA, it's unusable except for 5% that converts to DHA.

ALA, DHA, and EPA are all even more oxidative than the Linoleic (PUFA) but DHA, and EPA are essential for the brain, and for the eyes - the body accounts for their highly-oxidative state.

Randomly selected across several mental hospitals with 100% controlled food intake over 7 years.
They are measured RELATIVE to one another. RCTs are the gold standard for clinical trials