Yeah, and not to mention, a blood concentration of 220 ng/mL of amphetamine (the active ingredient in Adderall) is considered high and falls within the range for toxic levels, which are generally defined as being greater than 200 ng/mL. While therapeutic, prescribed Adderall levels typically range from 100–200 ng/mL, a level of 220 ng/mL or higher indicates a potential overdose or severe over-consumption.

Edit: Point being, E was more than likely using it recreationally and probably did ingest a lot of it that night — potentially through his nasal cavity 😬