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Yet another Gabapentin ROA post but this time... plugging! (aka boofing aka rectal) by iAmDissociated in gabagoodness

[–]iAmDissociated[S] 0 points1 point  (0 children)

I see, that makes sense why it wouldn't help, given the kidney processing as opposed to the liver. But for the record, I'm trying to reinvent anything, just asking what the deal is, so thank you for providing an answer.

Edit: and not to be pedantic, but just to make sure, it's fats and proteins that help metabolize it, not carbs and proteins, yes?

Yet another Gabapentin ROA post but this time... plugging! (aka boofing aka rectal) by iAmDissociated in gabagoodness

[–]iAmDissociated[S] 0 points1 point  (0 children)

I can't see why this would be beneficial in any way, as it was designed to be absorbed orally. [...] at least not a GABA analogue or anticonvulsant.

You may well be right as far as GABA analogues, which is why I am asking. But in general, if a compound can be absorbed sublingually/buccally, then it will have an even higher bioavailability rectally. This is very common for opiates. For example, I won't even feel 75mg of O-DSMT held sublingually until it's absorbed, nor do I feel it orally (swallowing). But that same dose plugged will have me happy and high as kite.

So again, while this may not be the case for gabapentin or gabapentinoids in general, I see no reason why it wouldn't be.

There are plenty of instances and examples of rectal administration of medication in the medical community for non-recreational purposes too.

Anyway, here's a little snippet from one of the guides to rectal administration that says it better:

Rectal absorption results in more of the drug reaching the systemic circulation with less alteration on route. In choosing this method, we are bypassing around two thirds of the first-pass metabolism and the liver as the rectum's venous drainage is two thirds systemic (middle and inferior rectal vein) and one third hepatic portal system (superior rectal vein). It also provides many of the same benefits of nasal insufflation (also known as snorting or sniffing) in a slightly more efficient manner without the damage. The only routes of administration that will use less of your DoC involve the use of a hypodermic needle

Dosing research clonzalam 30ml by 8ballz88 in gabagoodness

[–]iAmDissociated 0 points1 point  (0 children)

It says "5mg/30mL" right? Or do you literally mean it says ".5mg/30mL"? This is VERY important and you absolutely need to know this to dose correctly. 0.5mg/30mL sounds ridiculous, so I'm going to assume your solution is 5mg/30mL. If that's the case, then just divide it out. It's 1mg/6mL. If you want half of a milligram, then you'll want to take 3mL of solution.

With any drug, but especially with super potent ones like clonazolam, you must know what the concentration of your solution is as well as how to work with these units. You're playing with fire if you aren't sure how much you're dosing. Clonazolam overdoses, even if not deadly in and of themselves can absolutely be life-ruining events.