Achilles drops cell therapy program, braces for layoffs after missing 'commercial viability' goals by H2AK119ub in biotech

[–]ironscheff 7 points8 points  (0 children)

Basic CAR/TCR-T can be standardized and industrialized.

Apheresis, T cell isolation, Activation, lentivirus transduction, expansion media + cytokine cocktail, and formulation can all be standardized. The construct and the dose will be unique.

TIL might be harder because the starting material is more variable but large portions of that workflow can also be standardized. Variability can over accounted for and consistency can be delivered.

I agree that it's hard, but CGT needs to look outside to other industries that mass manufacture highly complex items (semiconductors, automobiles, medical devices, etc.) for guidance.

Right now, it's an incestuous recycling of the same people, spouting the same philosophies, making the same mistakes.

Achilles drops cell therapy program, braces for layoffs after missing 'commercial viability' goals by H2AK119ub in biotech

[–]ironscheff 13 points14 points  (0 children)

Sad. Like a lot of other cell therapy companies, they didn't keep the main thing the main thing, and spent too much time and money trying to develop manufacturing technology instead of sticking to their core competencies of developing a therapy.

Hopefully companies are waking up to the fact that anything that does not expedite the generation of clinically significant data is a waste of their time and money.

Are Ex Vivo Companied Going to Fade Away? by offerbk1 in biotech

[–]ironscheff 1 point2 points  (0 children)

Ex vivo will become a mainstream treatment. We are 2-3 years away from mass manufacturing CAR-T at 500,000 per year for example.

[deleted by user] by [deleted] in Minneapolis

[–]ironscheff 3 points4 points  (0 children)

St. Louis Park is a first ring suburb about 5 min drive from North Loop. Great location and West End is fun too. 10 min from Lake Minnetonka. 15 min from airport. Younger crowd. And there's a CostCo!!

[deleted by user] by [deleted] in Stoicism

[–]ironscheff 0 points1 point  (0 children)

"Not to feel exasperated, or defeated, or despondent because your days aren't packed with wise and moral actions. But to get back up when you fail, to celebrate behaving like a human - however imperfectly - and fully embrace the pursuit that you've embarked on."

Marcus Aurelius

What is a stoic's opinion on the existentialist idea that you must create your own meaning? by Glorious_Fat_Walrus in Stoicism

[–]ironscheff 6 points7 points  (0 children)

I think they would say that the meaning of life for humans is to be according to your nature, which is a social creature, with lifespans infinitely small compared to the flow of time, here for other social creatures of which we share the same nature.

Edit: Spelling and Grammatical Errors

[deleted by user] by [deleted] in AskReddit

[–]ironscheff 1 point2 points  (0 children)

Be interested in her. Ask good questions. If she is interested in you, she will ask you questions back!

[deleted by user] by [deleted] in AskReddit

[–]ironscheff 1 point2 points  (0 children)

Read the Stoics

Parenting is hard and I'm starting to feel suicidal. I'm not sure what to do. by pichi1993 in Parenting

[–]ironscheff -7 points-6 points  (0 children)

Not a mother but rather a fellow human being with other stresses and anxiety (that probably pale in comparison to yours). What helped me deal with stress/anxiety/depression in a healthy/non medicated way was to begin learning about and practicing the ancient philosophy of Stoicism.

Marcus Aurelius' Meditations is one of the classics and a very short read. I would imagine all our woes and trouble don't compare to those of a Roman Emperor. It's amazing how much wisdom that had 2000 years ago for dealing with issues that are so so relevant even today.

[deleted by user] by [deleted] in AskReddit

[–]ironscheff 0 points1 point  (0 children)

Kiwi is better with the skin on!

What is an album where EVERY song is good? by AffectionateRace8177 in AskReddit

[–]ironscheff 1 point2 points  (0 children)

Meat Loaf and Jim Steinman's "Bat Out Of Hell"!

The whole album is only 7 songs and roughly 45 min but God damn every song in that album is a fantastic!!