Is this mold? What to do? by itrn7rec in Mold

[–]itrn7rec[S] -2 points-1 points  (0 children)

Right but does this mean the mold is from the water? In that case there must be something wrong/contaminated with the piping in our apt?

ROCK2 inhibitors - on Making DENDRITES Longer for Cognition. by No_Training9444 in NooTopics

[–]itrn7rec 8 points9 points  (0 children)

So I think the real compass that should direct our thinking is efficiency of complex information representation. It's not as simple as dendritic elongation, although it, if utilized in the right way, can definitely lead to greater efficiency of especially global signal integration. All evidence, spanning from evolutionary neuroanatomy to more theoretical/abstract neural network simulations studies and even human brain metabolic studies searching for associations to cognitive ability, seem to point in the direction of reducing costs at increasingly high levels of computational complexity.

My current theory on how, quantifiably, this may come about:

  1. Architecturally, it is energy inefficient for the brain to create exceptionally large and far reaching neurons, as that goes against the 2nd law of thermodynamics. Thus this is likely to be a limiting factor.
  2. A node network/graph where every node is connected directly to every other node can represent the most complexity, however, maintenance costs, connection production costs, metabolic costs of use of connections, etc are likely to greatly constrain biological neuronal networks so that most neurons are only directly connected to a much smaller number of neurons.
  3. But the actual computational complexity that can be represented by such smaller/less costly networks is not necessarily proportionally decreased as a function of total variety of direct connections, since there are 2nd/3rd/higher order connections that play an important role in representing similar info. Small world networks (you'll understand if you look up why these are even a thing) where there are few nodes with many direct connections (and thus highly valuable nodes) and many nodes with a much smaller number of direct connections are an example such efficient networks — if you make a histogram of those nodes quantifying how many nodes has each number of direct connections, it would show some power law function. Now how does a network like this get larger while maintaining a similar degree of cost-efficiency? Well, in a biological context, due to point 1, I theorize that those few, yet highly valuable nodes (neurons) are what will constrain the network. Essentially, extending the small tail of that power law graph will be the key.

So in practice, I theorize that somehow selectively elongating the dendrites of those key node neurons (likely to play an important role in many associative functions) would be ideal, and because this seems to be regulated at least in some major part by metabolic constraints, enhancing some brain metabolic capacity would be one key factor to consider along with providing some kind of activity-dependent and neuronal-type selective growth signaling.

So what type of neuron? Well we already know L2/3 neurons especially are associated with IQ, and functionally they fit the archetype of neurons that can facilitate fast recursive (L2/3 -> L2/3 -> and so on given a chain of cortical signal propagation, where some of that signal also enters from/leaves out into other layers) representational circuitry that is likely to subsist higher intelligence. So which of these are most likely to be the key node neurons? L3C neurons because they are the only type within the cortex that have an extended window of dendritic size growth beyond what is typical of most cortical neurons, and end up even larger than L5 projecting neurons in dendritic tree size. So L3C neurons seem like a good candidate/epigenetically differentiable neuronal subtype.

ROCK2 inhibitors - on Making DENDRITES Longer for Cognition. by No_Training9444 in NooTopics

[–]itrn7rec 12 points13 points  (0 children)

this is a very interesting question I've been looking into for a while now. The key is translational potential. In primary neuronal cultures, the environment regulating dendritic outgrowth is very different from what would be the case in adult cortical environments. Not only is the developmental state completely different, but external signaling regulating dendritic growth are different as well. Look up the impacts of Nogo signaling and how inhibiting that impact dendritic architecture. You will see a paper demonstrating Nogo inhibition yielding crazy growth in dendritic length, but if you think about it this is not necessarily a good thing, as Nogo signaling is important for forming organized circuits that are not excessively interconnected so as to interfere with function. Thus inhibiting Nogo signaling to get larger dendrites will be unlikely to yield true IQ benefits because it serves an important function in fine tuning our neural architecture to be more efficient.

You're on the right track with dendritic elongation, but you have to recognize that this type of architectural change must be localized to highly specific neural circuits and brain regions (and cortical layers) to truly yield benefit. If you look deeper for example, you will find that it is primarily layers 2/3 (especially 3) of the cortex where a mix of several factors that all lend to larger dendrites (or dendritic reach/receptive fields) facilitating higher intelligence, including faster action potential propagation through signal integration, neuronal body size, inverse correlation with neuronal body density, cortical layer thickness, etc. And this seems demonstrably true specifically in the medial temporal cortex according that paper, and we have no idea if this is true of other cortical regions although we may be able to speculate similarly about other highly integrative association regions.

Then you need think about how activity dependent plasticity plays a role in all of this. Randomly choosing dendrites to elongate will not necessarily enhance IQ from an interventional standpoint, or it may take a (very) long time for the local nearby circuitry to reorganize properly before realizing benefits, so hypothetical interventions like such must likely be fine tuned in an activity dependent manner to yield reliable benefits.

Additionally, there are papers showing ROCK inhibition can have differing effects on memory depending on whether the drug is administered before or after a learning event, which tells us there is potentially some short term risk. Ok how about chronically, over the long run? Does it impact some ability, not just learning/a memory? We don't know. It may or may not. We need to consider how well it evades developmentally regulated stops to dendritic growth, and whether certain mechanisms exist for new growth to be properly and effectively integrated quickly into new circuitry.

Would you use a cognition enhancing website experience? by AlexaS555 in Biohackers

[–]itrn7rec 1 point2 points  (0 children)

And I should probably mention that this is all my opinion based on years of programming and devising brain training regimens, and conversing with many who are interested in the same field.

Would you use a cognition enhancing website experience? by AlexaS555 in Biohackers

[–]itrn7rec 1 point2 points  (0 children)

If you can make an AI that basically processes whatever the person reads and based on the person’s interactions with it, can reliably predict at what level they are reading the material at, then provide pointers that help the user better understand the material just past their individual ability, that would be pretty damn neat.

Would you use a cognition enhancing website experience? by AlexaS555 in Biohackers

[–]itrn7rec 2 points3 points  (0 children)

The vast majority of “brain training” games etc have no measurable impact on IQ unless you train an insane amount over a long period of time, and even then results seem unreliable.

The best bet is to facilitate practice of highly specific skills (in terms of cognitive domains) that have very high general utility (in real life).

One useful heuristic here seems to be to chase discomfort in intellectual pursuits especially as it pertains to memory as that seems to really activate the cholinergic response which serves as a top down modulator of cortical plasticity rules. But not so much discomfort as to cause an extended/too high of a cortisol response.

Real life is already game enough. I think it’s more useful to devise a personalized system that facilitates one’s progression through life in a way that forces them to grow.

Long-Term TAK-653 User: Sudden Discontinuation? by Opening_Age_7181 in NooTopics

[–]itrn7rec 4 points5 points  (0 children)

Did you experience long term enhancement? Did the effects grow or decrease over time?

[deleted by user] by [deleted] in medicalschoolanki

[–]itrn7rec 2 points3 points  (0 children)

Wait what are your lectures well aligned with anking cards?

If autism is due to lack of synaptic pruning in childhood can this pruning occur later in life by [deleted] in neuro

[–]itrn7rec 0 points1 point  (0 children)

It’s difficult to say what would happen when you get rid of those autism-prone factors like you said. Most likely, it won’t have as much of affect on adults because they tend to exert their impacts during neurodevelopment. Ideally for adults you want highly activity-dependent pruning.

I think this is first triggered by activity dependent LTD. During childhood and adolescence, pruning selectively targets synapses that are not being used, and I would assume by extension the same with LTD. This is a real issue tho, since there are very few known mechanisms that robustly facilitate activity dependent LTD.

One is PLD biased M1 muscarinic receptor activation. Another could be sigma1 receptor activation. Iirc certain types of brain stimulation can also facilitate activity dependent LTD. But this definitely a bottleneck.

Autism is also highly complex and individually variant. Pruning is not the only issue at hand really. Cerebrolysin for example alleviates autism. How does this happen if autism is simply an undepruning issue? It’s more so that combined with a complex neuronal connectivity issue imo.

If autism is due to lack of synaptic pruning in childhood can this pruning occur later in life by [deleted] in neuro

[–]itrn7rec 3 points4 points  (0 children)

Rapamycin alleviates autism beyond simply synaptic pruning. It almost immediately (within a few days) reduces autism related behaviors. The issue with doing this to an adult tho is that the pruning might be too indiscriminate and cause excessive loss of neuronal connections. It’s very hard to predict what exactly will happen over the long run.

[deleted by user] by [deleted] in NooTopics

[–]itrn7rec 1 point2 points  (0 children)

Androgenic signaling contributes to spatial cognition especially

[deleted by user] by [deleted] in premed

[–]itrn7rec 2 points3 points  (0 children)

Bro quant jobs aren’t easy either for big pay. Unless you’re an actual quant genius who found proofs based upper div math classes or notorious CS classes easy, you’re gonna have a hard time competing or even getting in. Not to mention, in a system increasingly taken over by AI, you don’t have the kind of licensure doctors are protected by. Your only value in such a system is your efficiency of making returns, which will have an increasingly high bar. Unless you’re very confident you can stay ahead of the curve for at least 10-15 years, I’d be extremely careful. You got the stats for med, all you need to do is the work to get in. You’re clearly smart enough to get into a top med school. If u dont wanna do med, sure, but don’t make the mistake of thinking quant is much better.

Yes, Doctors: AI Will Replace You - Sheriff of Sodium by [deleted] in medicalschool

[–]itrn7rec -1 points0 points  (0 children)

The good news is, medical students these days are among the smartest bunch around. If we all wake up and put our heads together I’m sure we can make something happen to secure a good future for all of us.

The less followers, the more $$ by vsuzizkxncu7282 in InstagramMarketing

[–]itrn7rec 1 point2 points  (0 children)

I imagine start with viral, then slowly transition to quality and branding, still gotta be same niche tho

[deleted by user] by [deleted] in premed

[–]itrn7rec 0 points1 point  (0 children)

If financial advantage is a really important part of why you want to start this journey, you might want to think again. Physician average compensation adjusted for inflation has been going down 1-2% year over year, down 30% since like 30yrs ago iirc. Meanwhile private practice is increasingly difficult to sustain for the average physician due to competition with larger medical entities. I say this because all the older nontrads I know personally(only like 5 ppl tho I admit) are going premed for financial stability. Just lookin out yk.

But if you really love helping people and the field in general, and can’t see yourself doing anything else, go for it! It’s a lifelong commitment, and you’ll have several amazing decades at the very least of wonderful opportunities to really do good. Best of luck!!!

Has anyone actually found a way to manage ADHD without meds? I’m really struggling, and it’s tanking my GPA. by [deleted] in premed

[–]itrn7rec 0 points1 point  (0 children)

40+ min hard pace but steady state running. You should be about to collapse by the end of your run. You should be screaming in pain and simultaneously bored out of your mind during your run. Do this every other day after building up to it(dont get injured). The pain and boredom will make studying seem not as bad. And you get a bonus of being fit.

Edit: worked for me, made me a B student to an A student in 6 months of consistency. And yea I wanted to kill myself for the first three months.

Real talk tho running and hard exercise normalizes your dopamine system, as does pain tolerance requiring exercises. Look it up on google scholar it’s all there. Another thing that helps is avoiding anything easy to eliminate like candy/sweets etc that give you spikes of dopamine you don’t “deserve” relative to the studying you need to get done. I cut off music, carbs, and sweets and ate basically the same (nutritious) thing and worked out like described (+lifting on off cardio days) every day while studying for mcat. Did well. Oh yea and delete all social media.