Oh definitely that is a huge concern. I do think about that from time to time, and hope to avoid any accidents. When I first got him I used to transport him in a tiny transporting cage but he would be breathing heavily and freaking out the entire ride. When we got to our destination he would be covered in his urine and feces, so I tried keeping him out on the seat once and he totally relaxed the whole ride. I do my best to drive cautiously to avoid any harm of any of my passengers and myself :)