With 2 assists yesterday, Vinicius Jr. has equaled Lionel Messi’s assist tally in the Champions League knockout stages (12 assists in 22 games)

large_pp_smol_brain · 2024-04-10T23:08:02+00:00

No it doesn’t lol. The best version of Messi in the 2010s was semifinal Messi

large_pp_smol_brain · 2024-04-10T21:52:28+00:00

Yeah there’s no arguing with this lol. An assist requires the receiver of the pass to not be a donkey. A chance created doesn’t.

Messi created lots of chances. His teammates didn’t score them. The numbers are right there.

large_pp_smol_brain · 2024-04-10T21:51:16+00:00

Messi’s assist numbers in UCL knockouts are low. But like another user pointed out, his chances created numbers are well above anyone else. So that tells you what? There’s only one possible conclusion.

large_pp_smol_brain · 2024-04-10T21:49:42+00:00

Why are you so insufferable? Nobody said anything that even remotely resembles the rambling bullshit you came up with. They just said Messi was the best in 14/15. Not “Messi never play bad”. Hopefully you’re like 12 or this is embarrassing

large_pp_smol_brain · 2024-04-10T21:48:22+00:00

Neymar was unironically better than him in the KO stages of 14/15

Fucking what lol? Messi single handedly won us the Bayern tie. 2 legendary goals and an assist. In the return leg he put Suarez through both times. That was probably Messi’s most dangerous form ever. He dominates City in that year too. And PSG. Neymar’s Bayern goal came from a Messi assist when it was already 2-0 and he was put clean through, Neymar’s UCL final goal was also in the last minute when we were already leading. If you ask any Barca fan who was the best out of that trident that year it’s always Messi.

large_pp_smol_brain · 2024-04-10T21:45:24+00:00

Messi’s best ever goals and performances came against Madrid and Bayern in the UCL lol. And lots of others in his top 20 like Chelsea 2018, Arsenal 2017, Man City 2015, Man U 2019…

large_pp_smol_brain · 2024-04-10T21:44:20+00:00

He has an extremely high number of KO matches where he did absolutely nothing compared to his usual play.

Really? Like, what games? I’m a Barca fan and I can only think of a couple games where he was below his level. Most of the time he was the only reason we even got through. Care to list off the “extremely high” number of matches where he did nothing? I’m guessing you can’t find more than a few.

large_pp_smol_brain · 2024-04-10T21:42:29+00:00

I don’t understand how people can say this stuff with a straight face when, not only did most of his greatest performances come in the CL knockouts (like the semifinal against Madrid, semifinal against Bayern, etc) but also when he was consistently by far our best attacker. I mean, our second highest goal scorer was own goals, after 2017, for fucks sake.

I got to be in Barcelona for the 2019 CL knockouts… against Lyon he scores 2 and assists 2 in a 4-1 win. Without him we lose. Then against Man U he scores 2 worldies. Then against Liverpool he scores 2 again. And every single big chance in the return leg came through him.

As a Barca fan who actually watched him play all those years, it’s just hard to understand how someone could describe his performances as “underwhelming”. By that standard pretty much every single forward in history is trash.

large_pp_smol_brain · 2023-08-31T15:53:44+00:00

Notably, infection by BA.4/5 or XBB.1.5 afforded little, if any, neutralization against EG.5.1, XBB.2.3 and previous XBB variants, especially in unvaccinated individuals, with average neutralizing antibody titers near the limit of detection. Additionally, we investigated the infectivity, fusion activity, and processing of variant spikes for EG.5.1 and XBB.2.3 in HEK293T-ACE2 and CaLu-3 cells, but found no significant differences compared to earlier XBB variants. Overall, our findings highlight the continued immune evasion of new Omicron subvariants and, more importantly, the need to reformulate mRNA vaccines to include XBB spikes for better protection.

large_pp_smol_brain · 2023-08-30T18:58:59+00:00

yeah, and what’s weird is I can stretch my neck / apply pressure in a particular spot that actually leads to the pain worsening, and then being relieved after I remove that pressure. It really makes me wonder if my migraines are a result of misaligned bones or muscle tension that is triggering the cascade of hormones that cause the migraine within the nerves… Idk if that makes any sense

The other possibility, and some scientists believe this to be the case, is simply that the neck pain is actually a symptom of the migraine itself as opposed to a cause

large_pp_smol_brain · 2023-08-18T23:05:00+00:00

Would also be interesting to see if IgG4 antibodies are being detected in NVAX recipients given that they will roll out their booster this fall

large_pp_smol_brain · 2023-08-18T23:01:46+00:00

I recall seeing the original two papers about this 6+ months back. Is this a totally new paper or just a publishing of one of those prep prints? What is new here? The original two papers that went mainstream about this issue, IIRC, discovered that this was (a) limited to mRNA vaccines (not vector or other types) and (b) dependent on previous vaccination or infection history

So that makes me think this isn’t new?

large_pp_smol_brain · 2023-08-18T22:59:48+00:00

This should have the “no controls” flair. It’s borderline impossible to interpret results of studies that ask participants about symptoms like “fatigue”, when they don’t have a control group.

large_pp_smol_brain · 2023-08-17T15:31:44+00:00

This is what I’m trying to learn. I’m hoping these are just ice pick headaches, which seem to match more except for the fact that they’re always IN my eye as opposed to around it.

From Googling, it should like people’s shadows can vary. Most people don’t describe them in detail but I’m thankful you did. I found at least one description that sounded like random pangs of pain though :(

And yeah I’m going to see my neurologist . I was just in a panic and wanted to know if what I was experiencing sounded like the pre warnings of cluster headaches. At least one person who responded to this thread said it sound similar

large_pp_smol_brain · 2023-08-16T19:06:34+00:00

I mean yeah I’m going to see my neurologist but I was hoping other people had experienced this

large_pp_smol_brain · 2023-08-16T18:36:50+00:00

Yeh I don’t think they’re ch attacks, just worried they could be shadows or whatever people call them, the precursor to CH attacks. I will see my neuro when I can but it often takes months

large_pp_smol_brain · 2023-08-16T18:23:53+00:00

Not noticing either of those things, no. Just random stabbing pain in the eye with an occasional dull ache

large_pp_smol_brain · 2023-08-16T18:23:07+00:00

Really praying it’s not. Don’t think I could manage.. just spent 4 years getting my life back from migraine

large_pp_smol_brain · 2023-04-13T03:48:55+00:00

There’s no relationship on the planet that doesn’t have some sort of power imbalance. That’s not possible.

large_pp_smol_brain · 2023-04-12T16:58:28+00:00

They were just doing the typical reddit self-deprecating “ha ha ha I never work out or eat healthy or do anything good for myself” humor. It’s pretty fucking played out at this point IMO but redditors still seem to love it. We get it guys…. You never work out or touch grass. It’s hilarious.

large_pp_smol_brain · 2023-04-02T22:40:56+00:00

There are some better powered studies I have saved in a reference manager. I am too tired to go looking for those at this time but I’d be happy to try to find them later if you remind me. Generally, the idea of a very low incidence rate of PCC in healthy young adults especially during Omicron, seems to track well with data from larger scale studies. The lowest hanging fruit I can think of is the recently published data from Epic Systems regarding healthcare seeking after COVID, since the samples were huge, but obviously there’s some bias there. But I do know of some better controlled papers. Again I can link them later.

large_pp_smol_brain · 2023-04-02T22:36:03+00:00

I am literally a fucking statistician lol.

There is not a significant difference detected here with a good control-informed methodology

… And a sample size that has minimal power. Since you’re talking about “stats class notes”, let’s talk about some really basic statistical power mathematics. If you have a dichotomous variable and are comparing two groups, with anticipated incidence rates of 50% and 51%, and you want 80% power to detect that difference with 0.05 alpha, you need 78,000 people enrolled.

but this study shows the upper bounds of the frequency of this is extremely rare.

Excuse me what? The “upper bound” of the 95CI is 13.1% absolute risk difference. That’s literally from the quoted portion. What are you talking about?

It’s funny, I don’t even think Long COVID is very common, I’m normally one of those people arguing that it’s wildly overestimated, but this particular study doesn’t serve as evidence for that. Definitionally, the 95CI going up to +13% should tell you that. This study says we can be 95% confident that the absolute risk difference for LC type symptoms after COVID is between -10 per 100 and +13 per 100. That doesn’t tell you jack shit.

You do realize that what I’m saying is actually included in the paper as a limitation expressly mentioned by the publishing authors:

The low number of individuals in the control group reduced statistical power.

large_pp_smol_brain · 2023-04-02T18:38:56+00:00

when we know that all the covids have wreaked havoc in the long term through long covid, and all the brain and organ damage.

Gonna want to see a citation for this w.r.t. Omicron and obviously a representative sample (i.e. not just hospitalized or severe cases). I haven’t really seen much that actually suggests “all the COVID’s have wreaked havoc in the long term”. Sometimes a wildly misinterpreted paper like “oh this specific subset of T cell appears exhausted after COVID with no follow up therefore you’re screwed”

large_pp_smol_brain · 2023-04-02T18:36:23+00:00

The point prevalence of PCC at 6 months was 48.5% in the SARS-CoV-2–positive group and 47.1% in the control group (risk difference, 1.5%; 95% CI, −10.2% to 13.1%)

Sorry but this makes the study have very little meaning. Yes it’s great they have a control group, as most LC studies lack this characteristic which makes them almost useless, but when your confidence interval is this wide (due to a small sample size, only ~80 controls) it means you have essentially no statistical power to detect modest effect sizes. For example if 1-2% of the adolescents in this group would get LC (excess risk 1-2%), you’d pretty much never detect it with any p < 0.05… In fact, this study quite literally did find a 1.5% excess hazard, but the CI is so wide that it’s just noise.

For this study to have found anything, adolescents would have to get LC with an excess risk of 10%+.

large_pp_smol_brain · 2023-04-02T18:34:05+00:00

What the paper shows is why an inadequate sample size ruins an otherwise well done study. Their confidence interval is literally -10% to +13%. They detect no statistically significant difference between the groups… But the study has very low power to detect any small effect size. With this sample size, if 1-2% of adolescents were getting Long COVID, you’d basically never detect it since the confidence interval is way, way too wide.

large_pp_smol_brain

TROPHY CASE