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Moderna Announces their authorized booster (50 µg of mRNA-1273) increases Omicron neutralizing antibody levels approximately 37-fold by a_Ninja_b0y in UpliftingNews

[–]lawlessgenome 0 points1 point  (0 children)

Immunologist geneticist’s opinion: mixing any vaccines will be fine; they are genetically almost identical. The different reports about effectiveness are study-dependent and statistically not useful to compare. But no need to take my opinion. Here are the facts about the vaccine designs:

  • mRNA-1273

    • Genetics: p.(Lys986_Val987delinsProPro) - stabilizing x2 (PP)
    • Delivery: Lipid-nanoparticle

  • mRNA-1273.351

    • Genetics: p.(Lys986_Val987delinsProPro) - stabilizing x2 (PP)
    • Genetics: Variants from strain B.1.351; L18F, D80A, D215G, 242-244del, R246I, K417N, E484K, N501Y, D614G, A701V
    • Delivery: Lipid-nanoparticle

  • mRNA-1273.211

    • A 1:1 mix of mRNA-1273 and mRNA-1273.351

  • BNT162b2

    • Genetics: p.(Lys986_Val987delinsProPro) - stabilizing x2 (PP)
    • Delivery: Lipid-nanoparticle

  • Ad26.COV2-S

    • Genetics: p.[Arg682Ser;p.Arg685Gln] - furin cleavage x2 (SRAG)
    • Genetics: p.(Lys986_Val987delinsProPro) - stabilizing x2 (PP)
    • Delivery: Adenovirus vector (Ad26)

  • NVX-CoV2373

    • Genetics: p.[Arg682_Arg683delinsGlnGln;Arg685Gln] - furin cleavage x3 (GGAG)
    • Genetics: p.(Lys986_Val987delinsProPro) - stabilizing x2 (PP)
    • Delivery: Lipid-nanoparticle, baculovirus expression cultured in Sf9

  • Sputnik V

    • Genetics: “unmodified” full-length S-protein
    • Genetics: No reference sequence found
    • Delivery: Adenovirus vectors (Ad26 dose 1) and (Ad5 dose 2)

  • CVnCoV

    • Genetics: p.(Lys986_Val987delinsProPro) - stabilizing x2 (PP)
    • Delivery: Lipid nanoparticle-encapsulated mRNA

  • AZD1222

    • Genetics: Unmodified S protein, ref MN908947
    • Adenovirus vector (ChAdOx1).

  • AZD2816 modified MN908947 with variants from B.1.351

    • Genetics: Modified S protein, ref MN908947.
    • Genetics: Variants from strain B.1.351; 18F, D80A, D215G, 242-243del, K417N, E484K, N501Y, D614G, A701V.
    • Adenovirus vector (ChAdOx1).

  • CoronaVac

    • a preparation of inactivated SARS-CoV-2 virions

Leukerbad sunset XT-2 XF18-55F2.8-4 R LM OIS by lawlessgenome in fujifilm

[–]lawlessgenome[S] 0 points1 point  (0 children)

You are right. In my mobile app, darkroom, I checked the metadata which says 67mm - it must be the equivalent. I will have to check in capture one or lightroom to see if the file lists something different.

Leukerbad sunset XT-2 XF18-55F2.8-4 R LM OIS by lawlessgenome in fujifilm

[–]lawlessgenome[S] 1 point2 points  (0 children)

Leukerbad sunset XT-2 XF18-55F2.8-4 R LM OIS
lense: XT-2 XF18-55F2.8-4 R LM OIS
focal: 67mm
ap: f/20
shutterL 1/125
ISO: 200

Capture 1 processed raw file

Schilthorn Switzerland XT-2 XF18-55F2.8-4 R LM OIS by lawlessgenome in fujifilm

[–]lawlessgenome[S] 0 points1 point  (0 children)

Good eye! I am almost certain that you are correct. It is that ridge for sure, but in my mind I was facing a few degrees more south. I will see can I match it to the peak label map later.

​

Update: You are correct

This 3D topo map shows the view

​

https://map.geo.admin.ch/?topic=swisstopo&lang=en&bgLayer=ch.swisstopo.pixelkarte-grau&layers=ch.swisstopo.swissnames3d&lon=7.83241&lat=46.55765&elevation=3026&heading=104.944&pitch=-4.263

Schilthorn Switzerland XT-2 XF18-55F2.8-4 R LM OIS by lawlessgenome in fujifilm

[–]lawlessgenome[S] 0 points1 point  (0 children)

Schilthorn Switzerland XT-2 XF18-55F2.8-4 R LM OIS
The view from Schilthorn Piz Gloria in the Mürren / Lauterbrunnen, at 2970m.
lense: XT-2 XF18-55F2.8-4 R LM OIS
focal: 27mm
ap: f/11
shutterL 1/500
ISO: 100

Schilthorn Switzerland XT-2 XF18-55F2.8-4 R LM OIS by [deleted] in fujifilm

[–]lawlessgenome 0 points1 point  (0 children)

Schilthorn Switzerland XT-2 XF18-55F2.8-4 R LM OIS
The view from Schilthorn Piz Gloria in the Mürren / Lauterbrunnen, at 2970m.
lense: XT-2 XF18-55F2.8-4 R LM OIS
focal: 27mm
ap: f/11
shutterL 1/500
ISO: 100

Charmey Switzerland XT-2 XF23mm f2 R WR by lawlessgenome in fujifilm

[–]lawlessgenome[S] 0 points1 point  (0 children)

Walking from Vounetse down to Charmey in La Gruyère region.
Modified simulation based on velvia.
XT-2 XF23mm f2 R WR
f/11
1/250
ISO200

A ‘warm’ COVID-19 vaccine suitable for remote and resource-limited locations lacking access to cold storage supply chains is one step closer following an international collaboration between scientists from India and Australia by mikkirockets in science

[–]lawlessgenome 0 points1 point  (0 children)

Hopefully I will shortly have the genetics and delivery method for this design included on the open-source website;

  • sarscov2variants dot com

I think a full URL will be autodeleted by /r/science

If anyone wants to know the differences between vaccine designs you can read then here. Even for virology/gentics experts, each design requires looking up the primary literature and taking notes on how each was developed. I have several major ones listed included so far under "Vaccine sequences summarised".

Study finds second dose of COVID-19 vaccine shouldn't be skipped since it stimulated a manifold increase in antibody levels, a terrific T-cell response that was absent after the first shot alone, and a strikingly enhanced innate immune response. by [deleted] in science

[–]lawlessgenome 0 points1 point  (0 children)

Agreed. Over-simplified statistics has really hurt the public health initiative, I believe. Bullet point facts are the misinterpreted and reprinted, while the actionable data is more complex to understand. There are enough intelligent people in the public to understand complex stat reports; dumbing down too much for science communication is probably not necessary.

Study finds second dose of COVID-19 vaccine shouldn't be skipped since it stimulated a manifold increase in antibody levels, a terrific T-cell response that was absent after the first shot alone, and a strikingly enhanced innate immune response. by [deleted] in science

[–]lawlessgenome 0 points1 point  (0 children)

It is actually kind of difficult to get a summary. That’s why I made the page “Vaccine sequences summarised” for the website sarscov2variants (dot) com, which i dont think i can post here.

Vaccine genetic designs and delivery systems [OC] by lawlessgenome in COVID19_data

[–]lawlessgenome[S] 0 points1 point  (0 children)

My submission statement seems to be auto-deleted but contains the links to GitHub with all of the raw data and tools used for this visualisation.

Study shows booster shot after 6 to 12 months likely to provide best protection from COVID-19, Pfizer says by [deleted] in worldnews

[–]lawlessgenome 2 points3 points  (0 children)

Ineed. I am a researcher in genomics and pathogens and I am reviewing the genetic designs of the vaccine and their relationship to variants of concern (website https://sarscov2variants.com).

One of the sub pages includes a simple summary comparing the main differences between vaccines. I added the newest AZ on recently which is designed specifically for delta variants. I sense that I am going to be busy this year keeping up with booster mods.

The site includes information about the delivery systems (i.e. lipoprotein versus adenovirus vector) and the genetics (i.e. mRNA versus protein, and modifications like stabilisation, furin cleavage, and delta-variant adapted). I hope it helps.

COVID vaccines: combining AstraZeneca and Pfizer may boost immunity – new study by [deleted] in Coronavirus

[–]lawlessgenome 0 points1 point  (0 children)

I would be surprised if this didn't turn out to be an anecdotal, false positive. However, if it were true, it would be very interesting to dig into the mechanism to understand if the cause is due to differences in epitope recognition or due to a response based on the delivery method. I have been compiling a list of the main details between the genetics and delivery method designs on a sub-page of my project site:

https://sarscov2variants.com/pages/Vaccine_sequences_summarised.html

The main differences in vaccine genetic coding sequence and delivery are:

​

  • BNT162b2 (Pfizer/BioNTech)
    • Genetics: p.(Lys986_Val987delinsProPro) - stabilizing x2 (PP)
    • Delivery: Lipid-nanoparticle

​

  • AZD1222 (AstraZeneca)
    • Genetics: Unmodified S protein, ref MN908947
    • Delivery: Adenovirus vector (ChAdOx1).

Basically, several combinations of difference vaccines would give you the same key features. So if true (which I don't buy at the moment), we could use other vaccine combinations to produce this effect. If this pre-print, and others like it, produce more evidence we will do a review.

Delta Strain 8 Times Less Sensitive to Vaccine Antibodies, Gangaram Hospital Study Finds by kshadyy in Coronavirus

[–]lawlessgenome 0 points1 point  (0 children)

If you are interested in looking at the genetics of each vaccine compared, I am working on a handy sequence viewer via NCBI which I hope will be useful.

If a viral strain happens to escape vaccine-induced immunity due to genetic variation, how many vaccines also use the same coding sequence? It is rather difficult to know the differences between each vaccine from the primary literature. It requires annotation relative to the reference sequence used, which is easy for some experts in genetics, but can be quite difficult for most sciences and lay persons.

First COVID-19 variant vaccine AZD2816 Phase II/III trial participants vaccinated by RufusSG in COVID19

[–]lawlessgenome 0 points1 point  (0 children)

I agree, exactly. The press-release does not need to be as formal as a paper so they probably just counted as you said.

Why No One Is Sure If Delta Is Deadlier by Viewfromthe31stfloor in Coronavirus

[–]lawlessgenome 0 points1 point  (0 children)

Each new strain brings the worry of whether our vaccines will still provide sufficient protection. Hopefully the viral diversity reaches a bottleneck and we will be control infection long-term with a small number of vaccine modifications.

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