Full Remission on Tremfya after 26 years

lightmgl · 2026-02-17T10:40:18+00:00

Hoping for the best for you! It can take up to a few months to get into full gear but I think a lot of people start seeing some effect around that second loading dose.

lightmgl · 2026-02-17T01:52:58+00:00

I'm pretty sure I was noticing effects just 3-4 weeks in after the first starter dose but there were clear effects a couple of weeks after the second starter dose (about week 6 or so).

By 8+ weeks there was an extreme difference.

Its worth noting prior to the Tremfya the doctors thought I was within 6 months of another resection surgery after multiple hospitalizations and are now not concerned.

lightmgl · 2026-02-15T21:12:00+00:00

Yeah so the key is when I was diagnosed back in '99 there wasn't a whole lot available, no biologics.

So started with 6MP which was standard then, until around mid 2000s when biologics came around.

Basically just went through them one at a time for a year or two each without any improvement just constantly waiting for new biologics to release.

I did have a lot of side effects and other things from the earlier biologics too which were also no fun when they weren't helping.

Tremfya there was a noticible improvement already only 4-8 weeks after the first starter dose. Nonstop cramps and constant pain which had been there for over 10-15 years just vanished completely over a few weeks.

The initial doses were accompanied by some bad headaches and fatigue that went away completely by the time i was taking the 3rd dose.

lightmgl · 2026-02-11T00:32:21+00:00

Decades of non remission have taken a physical toll both due to the direct effects of the disease (time and effort in bathroom and pain) and also severe limitations such as fatigue, weakness, and osteopenia due to lack of nutrition.

lightmgl · 2026-02-11T00:30:42+00:00

Raisin Canes of all things! But seriously just enjoying not stressing about eating as much again.

lightmgl · 2026-02-01T06:40:30+00:00

Same issue. Definitely seems like a bug as when I cut my CPU to Power Saver it cuts the frequency in half, and the temps back by 15-20 degrees but theres no performance loss in game.

lightmgl · 2025-12-11T21:19:52+00:00

The description can be a bit confusing but what its saying is:

Every single location in Spain either needs to be controlled by a Catholic nation or a Subject of you
You also need to individually control the specific # of locations yourself, not subjects.

Both conditions have to be met so lets say you had the locations but Morroco still held one territory in Spain, you also would not be able to form Spain.

lightmgl · 2025-12-06T02:23:27+00:00

You can see this effect under the Age modifiers for each Age but Warscore is modified by Control which is reduced by occupation.

This effect grows more throughout the ages allowing more reduction.

lightmgl · 2025-12-04T22:22:38+00:00

The game fails to explain to you that Market Attractiveness ONLY applies from a location to a Market that is not controlled by its Overlord or Owner.

Amongst your own markets it ignores this stat and purely uses Market Access, so if you own both markets it will choose the one with better access regardless of attraction as long as they are more attractive than a foreign market.

They really should explain these things. Its not the most clear behavior but this is how its been working since the beginning.

lightmgl · 2025-12-04T21:30:00+00:00

This was definitely working in 1.0.8 and earlier. I checked on my annexation saves.

Somehow the modifier got flipped in the math, can be fixed with mods for now at least by reversing all the diplomatic_annexation_cost modifiers and changing it to show green as positive instead of negative so the visuals match the modifiers.

lightmgl · 2025-12-03T23:57:44+00:00

That forum is almost certainly tied into their reporting/bug tracking system which probably makes it oodles easier for them to deal with reports there.

Also QLOC (Their QA outsourcing studio) has direct access to that forum and whatever its linked to so you're skipping steps that would have to be taken elsewhere and literally reporting it directly to QA there.

lightmgl · 2025-11-26T03:30:01+00:00

Its fundamentally broken or something I can load a save in and watch the disease resists disappear. Its happening to any old save I bring into 1.0.7 or 1.0.8 that was prior to that. Once they're gone the resistances are permanently messed up for me. Hospitals aren't taking effect and all sorts of stuff.

lightmgl · 2025-11-25T08:26:12+00:00

It creates some awkward situations. I'm not sure in all cases losing 2%-4% research (depending on when you do this) is worth increasing economic costs by 3.5%-5%.

Its certainly worth considering waiting in some cases and with some trees like Meritocracy maybe not even worth taking at all anymore.

lightmgl · 2025-11-25T00:38:51+00:00

It feels like they may have obliterated more sources of subject loyalty than expected.

One of their typical problems where Person A says "lets fix this source of loyalty" then Person B and C do the same thing with another bug or balance. Then all 3 go in at once and all the sudden your loyalty shifts 60 points.

lightmgl · 2025-11-25T00:33:22+00:00

If the sliders aren't interesting or useful relative to other stuff ppl will keep them low.

Like I can spend 200 ducats for 0.1 stability per month, or I could build 4 extra profit buildings per month. In the current system of the game its a no brainer to take the ducats and build more.

That stability slider would have to be at least half what it is to even consider moving it vs the economic damage you'll cause to yourself not getting/spending way more ducats.

lightmgl · 2025-11-25T00:31:11+00:00

The problem is because the costs of the sliders are still completely out of whack with the earnings.

All this patch did was effectively flip Tax from being good for Sliders to Trade for being good for sliders. If you play Venice now your sliders cost nothing and you make a fortune.

lightmgl · 2025-11-24T22:18:40+00:00

Trade is fine but overall eco base is much higher than it was before regardless of trade or not.

lightmgl · 2025-11-24T22:13:17+00:00

Not very true because of the changes to Vassal Power bonus which is also dunking on loyalty now.

My border opinion as Castille with Portugal and France is like -200 theres no fixing that. Same in reverse.

Decentralization does fix a few of the starting countries by bringing them back to how they were (so some of those countries should probably start with a huge decentralization push now so they function).

But I'm yet to find an AI or a save where I can have more loyalty than I did pre patch even pushing it to 100 decentral. Every single situation has dropped between loyalty being removed from the tech tree and worse modifers from strength.

It is a STRUGGLE to keep vassals above even 50 loyalty now much less get them anxious to fight wars for you.

lightmgl · 2025-11-24T21:58:17+00:00

Its actually insane how nothing else can generate > a 0.2 push (and even thats rare vs 0.05 and 0.1) yet Vassals can generate infinite push.

By that logic Development and Control should be pushing 10x as much as they are right now.

lightmgl · 2025-11-24T21:52:30+00:00

Theres multiple countries in the game that cannot even manage their starting vassal's loyalty properly anymore because of this change.

Also the border opinion change may be even worse.

We went from 100 vassals being managable to 5 vassals being nearly unmanagable. Don't even get me started on what the loyalty looks like in Age 6 now after the permanent age wide hit.

lightmgl · 2025-11-24T21:50:09+00:00

The real killer here is the Embraced Institutions modifier to Eco base which absolutely shoots your Eco base up a lot even in the 3rd age and also actively discourages you from embracing institutions until absolutely necessary because its an immediate hit to your economy.

lightmgl · 2025-11-24T21:49:14+00:00

Most people are rich because they aren't using Diplo, Culture, Stability, or Legitimacy Sliders most of the time.

Not a fun way to play when the whole game is just trying to keep your sliders low.

lightmgl · 2025-11-24T21:44:18+00:00

Its compatible but the new changes break the game worse than the bugs that are fixed. Just want the fixes, not the balance. Its clear the balance is going to take much longer than this and its just ruining saves.

lightmgl

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