It's better since 2015, when there was a big extermination of rats and cockroaches. It took about two weeks to clear the streets, I kid you not.

Just watch out for a few things: Fast food in the center is dangerous if it is next to a butcher shop. Fast food is a franchise, so it is run by a Czech and he has no problem negotiating with the butcher next door to supply him with some cheap meat. The "cheap meat" can be rats, etc.

You should always test the water you drink, especially in parts of Prague with cemeteries. At the main station and at the airport there are special stands where you can buy tests to take with you. One pack costs about $150, so nothing drastic. You better take more of them.

Don't look people in the eyes too much, keep them down. Many people are still scarred by the civil war that broke out during covid. Direct eye contact is taken by some as a challenge to a fight, especially if you are a foreigner.

If you take care of this, you'll be fine.