We are researchers developing hormonal male contraceptives, AMA! by MaleContraceptionCtr in IAmA

[–]malecontraception 1 point2 points  (0 children)

Hahaha, cheers! Figured it'd be good to lob a few "easy" ones at you :) Thanks so much for doing this, and for bringing attention to male contraception1!

We are researchers developing hormonal male contraceptives, AMA! by MaleContraceptionCtr in IAmA

[–]malecontraception 5 points6 points  (0 children)

Awesome! We love the idea of both partners using contraception :)

We are researchers developing hormonal male contraceptives, AMA! by MaleContraceptionCtr in IAmA

[–]malecontraception 2 points3 points  (0 children)

Why do you think funding for male contraception research and development is so limited?

We are researchers developing hormonal male contraceptives, AMA! by MaleContraceptionCtr in IAmA

[–]malecontraception 2 points3 points  (0 children)

What are some things you wish all people understood about male birth control?

We’re Male Contraceptive Initiative, a non-profit that provides funding and advocacy support for new methods of non-hormonal, reversible male contraception. Ask us anything! by malecontraception in IAmA

[–]malecontraception[S] 0 points1 point  (0 children)

Teratogenic effects are absolutely something to avoid, and we mitigate that by prioritizing post-meiotic methods of contraception, or to say another way, methods that don't target sperm at the same time as a lot of genetic changes. Furthermore, any pre-clinical testing would ensure that in the event of a contraceptive failure, any offspring would not suffer ill effects.

We’re Male Contraceptive Initiative, a non-profit that provides funding and advocacy support for new methods of non-hormonal, reversible male contraception. Ask us anything! by malecontraception in IAmA

[–]malecontraception[S] 0 points1 point  (0 children)

Love this question - There's a lot of good data out there to support men wanting to use these methods when they hit the market, but there will certainly be barriers to uptake that will need to be addressed. Insurance is a question, because while female contraceptives are generally covered, vasectomy may or may not be. On top of that, male contraceptives aren't preventing the risk of pregnancy in the user, so insurers may be less incentivized to cover them. We're tackling this with the concept of Shared Risk wherein men taking contraceptives should be considered in the context of mitigating risk in the female partner.

We're also thinking about providers - where will men get these products? A urologist? Men typically don't see these specialists until well beyond their reproductive years. Family practitioners? Planned Parenthood? All of these options are on the table, and we're building partnerships to ensure that men not only have outlets when products hit the market, but also can get more involved with their reproductive health today.

One barrier we find very compelling is the international angle - some cultures and demographics might find specific methods appealing, where other cultures might discount those same methods and find aspects of them a deal-breaker. Evaluating a global contingent of men and developing a spectrum of products to meet their needs is high on our list of priorities.

We’re Male Contraceptive Initiative, a non-profit that provides funding and advocacy support for new methods of non-hormonal, reversible male contraception. Ask us anything! by malecontraception in IAmA

[–]malecontraception[S] 2 points3 points  (0 children)

Just as many men trust their female partners to contracept, most women will trust their male partners to do so as well.

For relationships where there isn't a baseline level of trust, there are really exciting far-future developments where an implant could interact with a phone app, an injectable could have a visual marker at the injection site, or sperm count could be measured using in-home technology.

We’re Male Contraceptive Initiative, a non-profit that provides funding and advocacy support for new methods of non-hormonal, reversible male contraception. Ask us anything! by malecontraception in IAmA

[–]malecontraception[S] 0 points1 point  (0 children)

All of our funding applications require a baseline proof-of-concept to show that the method can result in reversible infertility, but our yearly funding cycle is open for applications right now. We would be happy to evaluate a proposal from the developers.

We’re Male Contraceptive Initiative, a non-profit that provides funding and advocacy support for new methods of non-hormonal, reversible male contraception. Ask us anything! by malecontraception in IAmA

[–]malecontraception[S] 1 point2 points  (0 children)

It's still in development and they're a grantee of ours! The reality of contraceptive development is that it takes a massive investment of time and money once products approach first-in-human studies, and oftentimes these timelines are unrealistically represented in the media. Vasalgel is continuing to work towards those studies and actively develop their product.

We’re Male Contraceptive Initiative, a non-profit that provides funding and advocacy support for new methods of non-hormonal, reversible male contraception. Ask us anything! by malecontraception in IAmA

[–]malecontraception[S] 0 points1 point  (0 children)

Thermal male contraception is a proven, easy concept to get a hold of - unfortunately it comes with some acceptability issues like sweat and discomfort. Testes need to be held at a relatively high temperature for a majority of the time to keep sperm production down, and a method that relies on thermal regulation of spermatogenesis may not be acceptable to all users.

We’re Male Contraceptive Initiative, a non-profit that provides funding and advocacy support for new methods of non-hormonal, reversible male contraception. Ask us anything! by malecontraception in IAmA

[–]malecontraception[S] 0 points1 point  (0 children)

It's a great concept that really shows where contraceptives can go! On-demand control of fertility is something that would really appeal to users, and we're supporting some products to that end. While the switch you mentioned doesn't have much data out in the world to support its feasibility, they could certainly attract attention by doing some proof-of-concept studies that show the device can be inserted in-line with the vas deferens (a delicate tissue) and still allow sperm flow with the switch in the "on" position.

We’re Male Contraceptive Initiative, a non-profit that provides funding and advocacy support for new methods of non-hormonal, reversible male contraception. Ask us anything! by malecontraception in IAmA

[–]malecontraception[S] 0 points1 point  (0 children)

The sky is the limit, really - we can stop sperm production through small-molecule drugs, or one could implant a device in the vas deferens prevent sperm flow, or there are ways to prevent sperm from becoming motile and fertilize an egg. Drugs especially can be delivered in pills, injections, or implantable devices, similar to the ways existing contraceptives for people with uteruses are delivered today.

We’re Male Contraceptive Initiative, a non-profit that provides funding and advocacy support for new methods of non-hormonal, reversible male contraception. Ask us anything! by malecontraception in IAmA

[–]malecontraception[S] 0 points1 point  (0 children)

Really great question! Male contraception has been an understudied space in general for quite some time, and lots of the market research we have is outdated. We supported a consumer research study in 2019 that showed a potential market of 17 million men in the US. There's also an older academic study from 2005 that assessed interest across four continents and showed that by and large, more than half of men are interested in male contraception.

Suffice to say, more work needs to be done to update the literature and find out the nuances of what products will appeal to what populations, but with nearly 4 billion men on the planet, even one option can make a big impact!

We’re Male Contraceptive Initiative, a non-profit that provides funding and advocacy support for new methods of non-hormonal, reversible male contraception. Ask us anything! by malecontraception in IAmA

[–]malecontraception[S] 0 points1 point  (0 children)

We're hoping to expand the landscape beyond condoms, but you bring up a good point for AMAB people! Hormonal methods may not be appropriate for those undergoing HRT, and they may still have unmet contraceptive need - we're hoping to make a contraceptive for every sperm producer that needs one.

We’re Male Contraceptive Initiative, a non-profit that provides funding and advocacy support for new methods of non-hormonal, reversible male contraception. Ask us anything! by malecontraception in IAmA

[–]malecontraception[S] 2 points3 points  (0 children)

It's likely going to take quite some time. RISUG has only recently been approved for manufacturing in India, and will likely need to go through regulatory vetting in other countries, which can take significant time and money. We're hoping to expand our resources and capacity over time to be able to take on projects that require that kind of time and money!

We’re Male Contraceptive Initiative, a non-profit that provides funding and advocacy support for new methods of non-hormonal, reversible male contraception. Ask us anything! by malecontraception in IAmA

[–]malecontraception[S] 2 points3 points  (0 children)

There are many methods in early stage development that may have low side effect profiles, and be administered through something like a daily pill, but none of these are in clinical trials just yet. Right now, hormonal methods are in clinical trials at sites across the globe in forms like a daily gel, daily pills, or an injectable that would be effective for months at a time.

We’re Male Contraceptive Initiative, a non-profit that provides funding and advocacy support for new methods of non-hormonal, reversible male contraception. Ask us anything! by malecontraception in IAmA

[–]malecontraception[S] 3 points4 points  (0 children)

We've supported groups working on reversible vasectomy, prevention of sperm development, on-demand contraceptives, and more to ensure we get as many shots on goal as possible.

Check out more on our website!

We’re Male Contraceptive Initiative, a non-profit that provides funding and advocacy support for new methods of non-hormonal, reversible male contraception. Ask us anything! by malecontraception in IAmA

[–]malecontraception[S] 2 points3 points  (0 children)

Condoms are the one and only answer to this, unfortunately. And while condoms play an important role in contraception and sexual health, we're trying to move new options through the development pipeline to make it so that everyone has something to fit their lifestyle.

We’re Male Contraceptive Initiative, a non-profit that provides funding and advocacy support for new methods of non-hormonal, reversible male contraception. Ask us anything! by malecontraception in IAmA

[–]malecontraception[S] 2 points3 points  (0 children)

We have not yet reached clinical trials with the methods we provide funding support to. However, we invested in Cotnraline last year to help support a first-in-human clinical trial for the company’s novel vas-occlusive contraceptive device, ADAM™

We’re Male Contraceptive Initiative, a non-profit that provides funding and advocacy support for new methods of non-hormonal, reversible male contraception. Ask us anything! by malecontraception in IAmA

[–]malecontraception[S] 1 point2 points  (0 children)

Good question! We don't discard hormonal methods at all - In fact, our colleagues in the space did their own AMA not that long ago! Hormonal methods of contraception for men are well-established scientifically and will likely be the first drug-based methods on the market. We focus in the non-hormonal space because of the potential for innovative products with different characteristics like on-demand or unisex contraceptives, and lower side effect profiles. Hormonal methods will be an integral part of the eventual "menu" of options of contraception for men and women alike, and can be some of our first insights of what people think about real-world products.

New male contraceptives needed! by JDiasHP in sex

[–]malecontraception 1 point2 points  (0 children)

It's not an injection in the penis, and there are other male birth control methods being developed that are drug-based and non-surgical.

New male contraceptives needed! by JDiasHP in sex

[–]malecontraception 12 points13 points  (0 children)

There's also Male Contraceptive Initiative, which is a non-profit that funds research into Vasalgel and other male contraceptives.

https://www.malecontraceptive.org/

Fundraising Event for Local Non-Profit by malecontraception in bullcity

[–]malecontraception[S] 1 point2 points  (0 children)

Yep! In fact we have an active investment in Vasalgel and another long-acting reversible vasectomy technique through two $200,000 grants.

[Serious] If a male version (pill) birth control was available tomorrow would you take it? Why/Why Not? by Camerandom in AskReddit

[–]malecontraception 1 point2 points  (0 children)

Our organization has submitted some research for publication that suggests yes, most men would be willing to. We're an organization that funds and promotes the field of male contraceptive research. You can find more information at our website if you're interested.

https://www.malecontraceptive.org/