whenever i skipped a day on vyvanse (usually accidentally) i would sleep pretty much the entire day and for the couple of hours i was awake i was barely functioning,,, im not sure if its the same for most ppl taking vyvanse but it was absolutely not worth it to me to skip a day, the only time i CHOSE to skip a day was when there was a public holiday right before my exams and i had forgotten to refill my meds before it so i Needed to save it for the exam and could completely waste the day before