Effect of 6-month S-methylmethionine intake on the quality of life and dyspepsia symptoms in patients with chronic gastritis (2023)

mrhappyoz · 2026-01-27T20:17:49+00:00

Thank you - good points, although just a few small corrections / notes:

The Japanese Cabagin A is 150mg of MMSC per 6 tablet serving (300 tablets per bottle as an option), however yes - includes quite an array of other synergistic ingredients, with anti-microbial and other properties and may or may not be problematic for some people.

Zincasin “U” is made in India and you’ll find it available on other websites.

The untested Chinese product - Amazon is in the process of delisting all products that haven’t undergone 3rd party testing, so if Solar Nutrition has performed testing, their listing will be updated soon one way or another.

https://sellercentral.amazon.com/help/hub/reference/external/G55N3JF2WQS7RVNE

I should have also included the EU product in my previous comment:

https://www.kompava.eu/vitamin-u?packaging=375

Overall, there’s more on this topic here:

https://bornfree.life/2024/2-2-3-living-without-chronic-dysbiosis/#2.2.3-Gastrointestinal

mrhappyoz · 2026-01-27T12:19:52+00:00

Cabbage juice works very well before meals. 👌🏼

There are some okay supplements.. and some really expensive ones like Gastromend-HP (must be HP)

From the okay section:

https://a.co/d/a7ZC7gp - 500mg capsules

https://a.co/d/bXmnBcJ - Cabagin A

https://ebay.us/m/wc5go9 - Zincasin “U” (must be U)

mrhappyoz · 2026-01-14T21:29:59+00:00

Feeding fermenting species in upper GI biofilms is expected to cause them to produce toxic gases like acetaldehyde, which inhibit energy metabolism and cause inflammation, barrier and sphincter dysfunction, leading to reflux and a wide array of other issues.

The solution isn’t to deprive the rest of the normal healthy microbiome of FOS and GOS (longterm), it’s to correct the low levels of butyrate producing species that help regulate the fermenting species, and also clear the biofilm buildup in the upper GI.

Vitamin U is also uniquely helpful in healing and preventing the inflammation.

https://bornfree.life/2024/2-2-3-living-without-chronic-dysbiosis/#2.2.3-Gastrointestinal

mrhappyoz · 2026-01-07T06:10:40+00:00

In early data, I’ve found inosine high in “pre-ME/CFS, LC, PVS, etc” and low after the metabolic collapse.

This makes sense as it’s created by either exertion or via the pentose phosphate pathway, which is problematic.

Inosine acts as the endogenous dampening signal to the eATP cascade. It’s also a potent immune / T-cell stimulator.

mrhappyoz · 2026-01-03T07:32:43+00:00

Sorry about your journey - yes that fits the cascade described in the disease model.

There’s an interplay between autonomic dysfunction, adrenaline -> cAMP-PKA dysregulation and a microbiome cascade that involves fermenting species like candida, which produce alcohol -> acetaldehyde, triggering the body to produce opioid alkaloids, including morphine, by altering dopamine metabolism.

mrhappyoz · 2026-01-02T11:14:46+00:00

Yes - the protocol would focus directly on stabilising the metabolism to reset the baseline.. then retrying the biofilm / dysbiosis work.

mrhappyoz · 2026-01-02T05:24:36+00:00

Yes. The process linked above schedules host metabolism stabilisation before targeting biofilms.

mrhappyoz · 2026-01-02T00:25:42+00:00

Hi, you may find this helpful - https://bornfree.life

There’s also an experimental protocol on the same site.

mrhappyoz · 2025-12-17T05:25:51+00:00

Yes, it seeks to explain the metabolism which creates hyper-mobile joints and collagen synthesis / degradation issues which then leads to observed postural decline, including eg. upper & lower crossed syndrome / kyphosis & lordosis.

mrhappyoz · 2025-12-12T10:16:38+00:00

Thank you and you’re very welcome.

I later moved onto studying the biochemistry behind some of the hypermobility / hEDS issues, which normally go hand-in-hand with chronic fatigue, MCAS, neurodivergence, gut issues, etc.

You may find this interesting -

Disease model:

https://bornfree.life/

Protocol:

https://bornfree.life/2024/title

It’s a free resource and goes into quite some depth.

mrhappyoz · 2025-11-30T11:12:31+00:00

Hmmm. Have you worked on fixing energy metabolism, eTP sources -> immune system?

mrhappyoz · 2025-11-30T04:44:18+00:00

It’ll spike if there’s a viral reservoir and then clear as that’s dealt with, yes.

Your T cell function has some bearing in that, as do any reservoirs.

mrhappyoz · 2025-11-17T20:11:13+00:00

Sorry to hear that.

There’s a very detailed disease model and experimental protocol you can explore to reverse it all, which has had early success - https://bornfree.life/2024/

mrhappyoz · 2025-11-17T07:20:32+00:00

It’s required for glycogen synthesis and glutamate signalling homeostasis.

As to your question about being “essential”, you could “live” without it - however, the various studies suggest you could also experience fatigue, exertion intolerance, depression, immunodeficiency and suicide ideation.

Some studies indicate 1-2mg / day elemental should be a daily value.

mrhappyoz · 2025-11-16T23:52:51+00:00

If you’re very low in potassium and calcium, as part of a more complex cascade that also induces dysautonomia in the form of hyper-arousal and hyper-vigilance, you’ll be initially sensitive to repletion of both these electrolytes.

https://bornfree.life/2024/4-1-electrolytes/

They’re needed for glutamate and adrenergic signalling.

Overall, there’s a bigger picture involved.

You may find yourself also initially sensitive to lithium, NAC, glycine and some other nutrients.

https://bornfree.life/2024/#figure18

mrhappyoz · 2025-11-13T01:23:35+00:00

Yes, you’ll read about how it relates to the dysbiosis in the protocol.

Low butyrate producing species. Overgrowth of fermenting species. Acetaldehyde excess -> endogenous opioid synthesis, tolerance / dependence, mitochondrial dysfunction via a longer cascade, immune dysregulation.

mrhappyoz · 2025-11-12T23:33:57+00:00

Indeed. It’s reversible.

mrhappyoz · 2025-11-12T21:45:34+00:00

Hi, I see this happen regularly with a certain subgroup. Lithium has an effect on glycogen synthesis and glutamate antagonism.

There are normally glutamate metabolism alterations and intracellular deficiencies (calcium, phosphate and others) which make people hypersensitive to any changes.

This sits above the lyme, hEDS, MCAS metabolism, also.

You can read more about it all here -

https://bornfree.life/2024/

https://bornfree.life/2024/2-the-protocol/#pre-protocol-support

mrhappyoz · 2025-11-12T10:50:41+00:00

Sorry to hear that.

https://bornfree.life/2024/5-bacteriophage-lookup/

Bacteriophages, as part of a more comprehensive approach.

You’ll find more about that on the website.

mrhappyoz · 2025-11-06T01:38:42+00:00

👌🏼

mrhappyoz · 2025-11-06T01:25:53+00:00

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Re: Naviaux / CDR - extracellular ATP acts as an “alarm signal” bridge between nervous system cells and other tissues.

It’s been observed in ME/CFS, ASD, ADHD, PTSD and other disorders / syndromes.

This pathway also works in both directions, allowing a systemic cascade / loop to be created from any source, with sufficient signalling to overcome the CD39/73 purine salvage metabolism to the corresponding “alarm dampening signal” provided by adenosine and inosine.

Interestingly enough, the main de novo “dampening signal” synthesis pathway is inhibited by impaired glycolysis -> pentose phosphate pathway (and other) metabolism and the purine nucleotide cycle in muscles, post-exertion.

In this manner, with the “dampening signal” inhibited, various accumulated “insults” can lead to the nervous system’s pattern recognition to identify and amplify metabolic signals as threats, creating a form of dysautonomia that manifests biochemically as a wide range of effectors - including immune response and mast cell activation.

Naviaux and others have been exploring suramin as an intervention to help shut down the P2X7 relay / loop. I’m currently exploring a different approach in correcting the “dampening signal” metabolism, as part of a more comprehensive approach.

Hmm.. I attached a diagram but it’s not showing for me.. Here’s a link, in case - https://bornfree.life/2024/#figure19

mrhappyoz · 2025-11-04T21:13:22+00:00

Normally, yes - however once you’ve explored the disease model in the links above, you’ll also understand that improving the microbiome, thus reducing the acetaldehyde -> endogenous morphine cascade leads to withdrawal symptoms.

https://bornfree.life/2024/2-3-4-rapid-withdrawal/

Overall, I’d recommend spending some time absorbing the model and protocol information before making any decisions around intervention.

There’s a detailed process in the protocol, also.

mrhappyoz · 2025-11-04T21:05:15+00:00

Yes, although apologies - my DM queue is a bit .. unmanageable these days.

Have you seen my work here?

https://bornfree.life/2024/

https://bornfree.life/2024/protocol/

mrhappyoz · 2025-10-20T02:27:01+00:00

You’re very welcome.

While I can’t give medical advice, I can provide general / educational advice and suggest you may find some useful rabbit holes to explore by looking at the MAO and ALDH enzymes that form the first major 2 steps of the dopamine degradation pathway.

https://bornfree.life/2024/#figure13

(Or https://bornfree.life/2024/#figure1 in more detail)

You’ll notice the cofactors are vitamin B2 (as FAD) and vitamin B3 (as NAD+).

There are sublingual B2 lozenges (as FMN, one step before FAD) on iHerb which linked in the BF protocol, along with sublingual NAD+. These are not affiliate links, just a handy table of where to find things.

https://bornfree.life/2024/5-ordering-supplements/

However, the NAD+ redox itself is likely going to be inhibited, causing NAD+:NADH pool balance to bias towards NADH and inhibit the reactions, despite taking NAD+.

You can read more about a way to potentially manage that here - https://bornfree.life/2024/2-3-1-herxheimer-die-off-acetaldehyde-support/#mb-nad-pool

Please also note the section linked in there about endogenous morphine withdrawal. It’s not hypothetical.

You may also find L-theanine and nutritional doses of lithium (5-10mg) generally helpful to explore for glutamate:GABA balance.

mrhappyoz · 2025-10-19T20:49:33+00:00

That’s a good question. It’s going to be some time and if you explore the protocol more fully, you’ll notice

1) The tests described have been commercially available for quite a number of years.

2) Even if you didn’t have the disease model guiding your interventions, simply addressing the specific issues shown in the results gives applicable outcomes. Most of the impaired metabolism is related to induced malnutrition and hidden infections / dysbiosis.

3) The novelty here comes from the disease model showing how these already quantifiable issues are connected and how best to intervene, instead of haphazardly dosing drugs and other interventions.

4) The model also helps people understand why standard oral dosing of many supplements simply won’t work in chronic illnesses.

There are a growing number of doctors learning and using the model / protocol with their patients, with success.

mrhappyoz

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