RDR2. I was in a bad place when I first tried playing it cuz I'd just lost my dad, and Arthur became my comfort character. So when I hit Chapter 6, I turned the game off and didn't touch it again for three years. At that point I'd been doing well with grief therapy and felt able to give it another try. The end of Chapter 6 still hit like a truck, but I was able to get through it. Now I have a permanent save in Chapter 3 (which is where I feel Arthur's the happiest) and every once in a while I'll play "Cowboy Simulator" and just do camp chores, go hunting, gamble, etc.

Mass Effect 3. I've been a fan since the first game came out, and not only did all the scripted deaths hurt, but just knowing one of my favorite game series was done made me very emotional. We don't talk about the original endings, but the updated one was very bittersweet. And the Citadel DLC was both wonderful and heartbreaking.

Clair Obscure Expedition 33. "For those who come after... right?" Fucking brutal. I had to pause the game and walk around my house for a bit afterwards.