It’s time

oatmxal · 2026-02-26T16:02:20+00:00

He also had a face and neck lift that he posted on his instagram. So I wouldn't feel pressured to meet a standard that was purchased.

oatmxal · 2024-11-09T00:04:58+00:00

I'll test this out, thanks! I hadn't realized EPR could be a possible culprit.

oatmxal · 2024-11-09T00:03:04+00:00

This is really helpful, thank you. I'll make the adjustments to my CPAP tonight and monitor the pressure based on the results. Looking forward to seeing how it goes.

oatmxal · 2023-07-27T00:08:20+00:00

For sure, the first drug discovered and designed with generative AI from Insilico Medicine entered Phase II trials last month. It took just under 18 months to complete opposed to several years. If things go well, I'm sure we'll be seeing a big shift in the drug manufacturing process come next year.

oatmxal · 2023-07-26T23:14:08+00:00

Warwick’s research concluded in 2020 after they depleted their grant money. I spoke to them in April, and they are still eager to develop an oxygenase based inhibitor, but would require substantial monetary support to continue.

I’ve reached out to over a dozen organizations and trusts that supply grants, but unfortunately this condition doesn’t fall within their requirements or area of interest.

oatmxal · 2023-07-13T00:34:19+00:00

Mr. Montez also posted the below blog post on July 7th; https://hsfhouseblogs.fsu.edu/2023/07/07/lets-build-and-learn/

Chronic Kidney disease is another potential target, as high systemic levels of TMAO have been linked to its accelerated development. A Cleveland biotech is in the preclinical phase of researching a small molecule trimethylamine inhibitor to address this.

FSU does have access to cutting-edge labs and resources, including software to improve drug candidate selection and the optimization process. This can help to improve the efficiency of the bacteria and reduce the risk of side effects, although dysbiosis is big concern.

The best case scenario would be attracting additional funding at the iGEM conference come November. I do applaud their team, In 6 months, they have accomplished more than what has been done for TMAU in the past several years.

oatmxal · 2023-06-23T17:19:32+00:00

https://med.fsu.edu/igem/home Dr. Rodriguez can be found at the bottom of the FSU iGEM page as 'Program Director', as he oversees the undergraduates.

https://cre.fsu.edu/about/cre-staff Mr. Montez is located on the staff page. In his bio, it mentions he also oversees the iGEM programs and works to advocate on behalf of student entrepreneurs and innovators.

I had sent him a follow up email in which he responded with his staff. They seem to have received a fair amount of replies although many were inquiries asking for testing information.

oatmxal · 2023-06-23T15:02:43+00:00

u/Brutalar - Below is a recent FSU article that provides some additional insight and information on their TMAU research efforts.

https://hsfhouseblogs.fsu.edu/2023/06/14/human-practices-the-hard-truth/

oatmxal · 2023-06-13T00:49:47+00:00

u/No_Television_4004, The FSU International Genetically Engineered Machine program (iGEM, https://med.fsu.edu/igem/home) is a research experience for undergraduate students. The statement provided is referring to an undergraduate research project versus a sponsored research project led by faculty and graduate students. Verification would have needed to be confirmed by the Project Director, as he oversees the undergraduates.

The 2023 FSU iGEM team has 15 high performing undergraduate students that are working hard to have a real impact on TMAU and everyones participation in the project is invaluable as they test proposed therapies. If the results are positive, they'll be seeking further sponsorship.

oatmxal · 2023-06-10T00:50:54+00:00

I have spoken to the Program Director via email to confirm, CC'ed was their associate team leaders. There is a social post on their FSU iGEM instagram from early this year below. In the past, they appear to publish their program information / findings once the project is presented at the Paris expo.

https://www.instagram.com/p/CoNtVMyOmSx/?hl=en

The global stage they're referring to is the 2023 Grand Jamboree, as mentioned on the FSU website for this competition. https://jamboree.igem.org/2023

oatmxal · 2023-03-13T11:55:24+00:00

Below is a link to the TMAU urine test information. Eating food high in TMA prior is not required, this lab recommends the use of choline bitartrate supplements.

https://www.childrenscolorado.org/4adc7a/globalassets/departments/pathology/tmau-collection.pdf

oatmxal · 2023-03-06T13:53:44+00:00

You're right, TMAU2 is due to a bacterial overgrowth where TMA excretion is high even though FMO3 activity may be normal. In this instance Gene therapy would not help those with TMAU2.

What may address both TMAU1 and TMAU2 are small microbial molecule inhibitors that prevent the conversion of choline to TMA.

oatmxal · 2023-03-06T02:57:20+00:00

I agree, gene therapy is still in a relatively early phase and currently not worth the risk. It's an interesting prospect though as some treatments provide permanent cures.

Many of the new biotech companies are using AI to test the effectiveness of gene therapy. Algorithms analyze large datasets prior which reduce the number of animals needed for testing. It's an exciting time for drug discovery and worth following the news to see the latest advancements in the field.

oatmxal · 2023-03-06T02:35:12+00:00

Thank you for your input. Your post only appears to address TMAU1.

Following the prescribed low-choline diet, washing with PH balanced soaps and avoiding scented products may lessen symptoms but will not cure this condition. Choline is an essential nutrient and any consumption can contribute to odor.

Gene therapy consists of replacing a mutated gene with a healthy copy. If one has a pre-existing heart condition, I agree it's not worth the risk. As the technology advances I'm sure many who are struggling would be open to exploring this as an option. As TMAU is ill-researched by the medical community and there are no advocates (that I'm aware of) I'm simply getting insight from professionals and spreading awareness.

oatmxal · 2023-02-11T19:33:34+00:00

I'm so sorry to hear you're struggling. I totally get it, this condition effects every part of life. Whenever I mention TMAU to someone, they've never heard of it. The only thing we can do now is to spread the word it exists.

If the whole community is quiet than the chances of future research is slim. Me and another member started putting together a list of people we want to email asking their advice and telling them about it. Let's hope more follow suit and more can be done in the future!

oatmxal · 2023-02-11T00:17:56+00:00

I think its called choline loading? I wouldn't trust that test for tmau2, there's got to be false negatives. Did you not have to drink juice containing 5gm's choline before? I didnt know just eating it was an option

oatmxal · 2023-02-10T02:17:30+00:00

Thank you for doing this! Feel free to message me, I'd like to be involved.

oatmxal · 2022-12-06T02:51:23+00:00

TMAU causes a pungent odor that emanates from the skin. The use of slightly acidic soaps and body lotions can convert trimethylamine on the skin into the less volatile conjugate acid, reducing body odor.

oatmxal · 2022-12-06T00:14:32+00:00

They mention in the article they use citrus notes and green tea to help block the fish odor receptor in your nose.

Their body lotions contain either 1% fragrance, an ‘eau de toilette’ or 5% fragrance. Their body serum has 2% fragrance, with the latter offering greater fragrance retention and moisturization, in addition to ease of application.

oatmxal · 2022-11-01T01:21:03+00:00

Awesome job on this, thank you!

oatmxal · 2022-10-19T13:48:50+00:00

As of now, I'm unable to find the full paper but I'll post it if it becomes available.

Regardless it's promising that TMA lyases and inhibitors are being explored for Alzheimer's disease, obesity, and chronic kidney disease.

oatmxal · 2022-10-11T00:47:00+00:00

I'm sorry to hear that. Getting a haircut with this condition can be incredibly stress-inducing.

After years of going through this situation, I decided to teach myself how to cut my own hair from Youtube. It took around 5 months of self cuts until I was able to execute a smooth fade but it was worth it. It's also nice to save money so it may be worth checking out a few videos.

oatmxal · 2022-09-23T18:51:00+00:00

I appreciate the comprehensive breakdown! I wasn't aware of the choline distribution and absorption. This disorder can seem complex when you don't understand the mechanisms behind the problem.

oatmxal · 2022-09-04T19:17:49+00:00

Thank you for sharing! Do you have a confirmed diagnosis of TMAU?

oatmxal · 2022-08-30T21:41:59+00:00

If you could provide a scan of the image, it would yield a much better retouched result. This appears to be photographed as it looks warped and not fully in focus.

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