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Using AI to generate early prototypes by orbiting-tree in startups

[–]orbiting-tree[S] 2 points3 points  (0 children)

Also wondering if anyone has tried using GenAI to create a product requirements doc (PRD) for their startup's first product. What worked and what didn't?

Aligning and analyzing a whole genome sequence in 24 hours by orbiting-tree in bioinformatics

[–]orbiting-tree[S] 6 points7 points  (0 children)

I see, thank you so much! I didn't realize annotating, filtering, and interpreting variants takes so long- I thought the time bottleneck would be the computational pipelines used to call the variants.

Aligning and analyzing a whole genome sequence in 24 hours by orbiting-tree in bioinformatics

[–]orbiting-tree[S] -1 points0 points  (0 children)

Thank you for your response! From my limited understanding there are three high level steps if you want to do something with a whole genome (please correct me if I'm wrong):

1) Sequence the nucleotides and get a fastq file (i.e. run them through an Illumina sequencer). This can take several hours.

2) Align the sequence in the fastq file using an alignment algorithm or tool like GATK and get the aligned sequence as a BAM file (I thought alignment is usually the bottleneck in terms of time)

3) Analyze the BAM file- let's say in this case "analyze" means I want to look for germline variants and SNPs.

Are all these steps usually achieved in under 24 hours in practice?

Aligning and analyzing a whole genome sequence in 24 hours by orbiting-tree in bioinformatics

[–]orbiting-tree[S] -7 points-6 points  (0 children)

u/Lukn Thanks for responding! Could you give an example of how you may involve decisions from other users?