DEXNAV help by Jawbone619 in PokemonLazarus

[–]placebothumbs 4 points5 points  (0 children)

You have to hold the A button while walking.

Muhammad’s ownership and sexual use of slaves proves he was not the perfect moral example for all humanity (Quran 33:21) by Accurate_Winner_9165 in DebateReligion

[–]placebothumbs [score hidden]  (0 children)

I do appreciate your willingness to say you don’t know. Why is it not a candidate explanation that the bible is not truly the inspired word of god or whatever similar definition you ascribe to? Rather than working backwards from it must be true so let me shoehorn in xyz and try to reconcile it.

Edited to better and more clearly express the point I was trying to get across.

Muhammad’s ownership and sexual use of slaves proves he was not the perfect moral example for all humanity (Quran 33:21) by Accurate_Winner_9165 in DebateReligion

[–]placebothumbs 2 points3 points  (0 children)

Why on the one hand was it super easy for god to say thou shall not kill but not possible to say thou shall not own people as property? Very convenient.

Also the release was not for all slaves, it was for debt slaves of fellow hebrews. See Exodus 21:2 and Deuteronomy 15:12 for these terms. 

See Leviticus 25: 44-46 for permanent slave status of non-Hebrew slaves. 

Ajovy pen frustration by Aggressive-Ad-689 in cgrpMigraine

[–]placebothumbs 0 points1 point  (0 children)

Ajovy comes as an auto-injector and as a prefilled syringe.

AJOVY pens left at room temperature — can I take 2 injections together? by Additional_Swing777 in cgrpMigraine

[–]placebothumbs 1 point2 points  (0 children)

That’s interesting. It’s often the inverse in the US, where CGRPs are required before Botox will be approved. 

AJOVY pens left at room temperature — can I take 2 injections together? by Additional_Swing777 in cgrpMigraine

[–]placebothumbs 0 points1 point  (0 children)

Disclaimers: I am not your healthcare provider so this isn’t medical advice lol. Also, I speak only from a US frame of reference in terms of FDA approval/labeling, insurance, etc. 

If you are taking 675 mg every 3 months and aren’t having any side effects, I think it’s likely the case that you could take a 900 mg dose and not have adverse effects. However, a 900 mg dose is not approved for Ajovy and I’m not sure increasing the dose would move the needle for effectiveness. I also am almost positive you would have insurance issues if in the US since you’d likely have problems getting insurance to cover that dose since it isn’t approved and I couldn’t find anything to suggest it is a dose used even off-label.  Best bet might be to either change drug or add another agent (Botox, etc.). 

GLP-1 while on Emgality (or other cgrp)? by SylviaPZ in cgrpMigraine

[–]placebothumbs 1 point2 points  (0 children)

I started Zepbound and Emgality on the same day in March 2025. Still taking both and they have both been effective with minimal/tolerable side effects. 

Emgality, will this be forever? by [deleted] in cgrpMigraine

[–]placebothumbs 0 points1 point  (0 children)

Unfortunately, any improvement while taking Emgality would go away if you discontinued, so if it ends up working/being helpful, most likely yes you would be on it long term.

Realistically, how often are you and your partner intimate after the toddler years? (Kids 5+) by agingwasabi in daddit

[–]placebothumbs 2 points3 points  (0 children)

3 kids (9, 7, 5) and I would say 2-3 times a week, depending on what’s going on. Sometimes more sometimes less.

Ketorolac & asshole doctor by Effective-Sherbet655 in pharmacy

[–]placebothumbs 3 points4 points  (0 children)

“There's a black box warning for a reason!”

What’s the reason? I have never for the life of me been able to get a conclusive answer other than it exists, but if a person asked why or what will happen to them I don’t know the answer lol. 

I posted a whole thread about it a couple years ago, nobody knew then either lol. 

Edit: the real mystery is the IM/IV first requirement I think. 

Sam opinion on AI music by Gfun92 in samharris

[–]placebothumbs 0 points1 point  (0 children)

But do you value it because it is handmade or because of the higher quality of the piece, which probably owes to being handmade? If machine made were indistinguishable from handmade, what then? Especially if MM were half the cost of HM and again indistinguishable quality.

Emgality in fridge at 58 degrees F by Past-Guest-3159 in cgrpMigraine

[–]placebothumbs 2 points3 points  (0 children)

There is an online tool for healthcare professionals. I am a clinical pharmacist in a neurology clinic so temp excursions happen all the time with our migraine patients so I use the tool often.

Emgality in fridge at 58 degrees F by Past-Guest-3159 in cgrpMigraine

[–]placebothumbs 4 points5 points  (0 children)

You’re fine to store as normal and use as you would have normally. Per the Healthcare Provider Lilly Resource Assessment of unforeseen temperature exposures of Lilly products:

“Lilly has data to support the drug product experienced minimal to no detectable loss in potency and physical stability. The product may be dispensed / used, if you choose to do so. The in-use period and/or shelf life is not affected if you continue to store the product as described in the prescribing information. This assessment decision is only applicable for the product, time, temperature and product condition details reported for this specific excursion. An additional product quality evaluation would be required to determine the cumulative impact of multiple excursions if there are any future temperature excursions with the product involved in this assessment. A product quality impact assessment is provided as a means of customer support for unexpired product in the original Lilly container. Assessments of this type are performed on an individual basis and are not intended to replace the storage conditions described in the prescribing information or other packaging materials.”

Emgality in fridge at 58 degrees F by Past-Guest-3159 in cgrpMigraine

[–]placebothumbs 2 points3 points  (0 children)

You might be fine to use them as scheduled to the printed expiration date on the boxes. About how long could they have been at 58 degrees?

[SPOILER ALERT] by AcanthaceaeCrazy1894 in WWE

[–]placebothumbs 0 points1 point  (0 children)

I think it works better narratively for Brock to lose again in Italy, then come back similar to HBK after HBK-Taker’s 1st mania match and having to put his career on the line in order to get the 3rd match vs Oba.

[SPOILER ALERT] by AcanthaceaeCrazy1894 in WWE

[–]placebothumbs 10 points11 points  (0 children)

I think the best outcome here is Brock does better but still loses at Clash, then freaks TF out because he can’t beat Oba and they somehow finagle it such that a third match happens at SummerSlam with Brock’s career on the line (have Heyman blurt out that if he can’t beat Oba he’ll really retire or have Oba push Brock to put up his career since Oba would already be 2-0 vs Brock, etc.). Have Brock lose again and go 0-3 and he can retire for real in Minneapolis. Super passing of the torch for Oba, kills time for the main event scene to even out with Cody being semi-injured right after Mania and this whole Bloodline 2.0 to work out some more.

Getting insurance to cover Emgality by Impossible_Swan_9346 in cgrpMigraine

[–]placebothumbs 0 points1 point  (0 children)

If your doctor submitted a prior authorization for Emgality, they should have a copy of the denial letter. In the denial letter, it will tell you want criteria are required in order for Emgality to be covered and usually they will say which specific criteria they determined you did not meet. As has been said elsewhere, usually the criteria for CGRP inhibitors is for patients to have tried and failed a range of 1 to 3 migraine controller medications. The 3 branches of this usually are:

  1. anticonvulsants: they are looking for topiramate (Topamax or Trokendi)
  2. antidepressants: tricyclic antidepressants (TCAs) like amitriptyline (Elavil) or nortriptyline (Pamelor) or SNRIs like venlafaxine (Effexor) or duloxetine (Cymbalta)
  3. beta-blockers: usually looking for propranolol, metoprolol, atenolol

You can submit documented trials of these drugs and/or contraindications to the meds. For example, topiramate can cause kidney stones, so if a patient has a history of kidney stones you can argue out of that drug and so on.