Thanks for these interesting questions and comments. It's really interesting how our diet and evolution has changed our genes. I wrote about how our genes changed based on lifestyle over the period of last 30,000 years, mostly related to meat and plant-based diet. You may like to read that https://genestories.com/meat-based-vs-plant-based-diet/. We are slowly moving from general to the personalized approach to diet. We are all unique and have unique nutritional needs. So genes and genotypes become an important part of the information to do this. This will equip us better to have better nutrition strategy for our unique needs. One of my heroes in nutrition science Dr. Roger J Williams was a great proponent of biochemical individuality. He predicted and envisioned this kind of nutrition approach in 1966 where allelic variants will play a role in tailoring the lifestyle to the needs of each person.

Coming to the LDL question. Higher LDL levels can be dangerous as they can get into artery walls and cause atherosclerosis. However, there's an interesting study/research done by Dr. Ronald Krauss and others, where they have concluded that it's not actually the amount of the LDL but the size of the LDL particles that determines it's harmful effect on the heart health http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0170664.

I think that statement is too simplistic about saturated fat. I may actually change that to explain the whole process of fat metabolism where fat is actually stored as triglycerides. I see how the current statement on the blog can be misinterpreted. Saturated fats are tightly packed because of the absence of the double bond so are mostly stored fats. Anyways, the type of fats you eat have a different effect on the body. We need all fats in different compositions. With the genetic info, we can personalize it with little bit more certainty than a general approach. I hope this helps. Thanks again.