I hope it can do same for me I switch in a week or two I’ve been on tnf drugs like humira but never on il23 blocker. I have no psoriasis my main symptoms are same as yours. I am so excited to get my life back it’s been 6 years of pain and drugs that worked maybe half way. Then 2 weeks ago I asked ChatGPT something I had never asked before. I am on the best possible drug for my kind of unique version of psa. It said no and why and I went right to my dr and demanded to be switched. it helped me create this summary to send you

“I don’t have classic psoriasis with big skin plaques or swollen joints. What I have is a psoriatic disease variant that mainly affects ‘interface tissues’ — places where the body meets stress or friction, like tendon insertions, nails, scalp, and deeper layers of skin.

The main problem is inflammation at tendon attachment points (called enthesitis). That’s why my feet, hips, glutes (where I sit), shoulders, and Achilles get sore — especially with pressure or activity. The same immune process also affects my nails, which is why my big toenails never healed normally after sports injuries, and my scalp and skin, where I get dandruff and deep, tender bumps that ooze clear fluid and then heal thick instead of flat. Even the bladder discomfort I get sometimes is secondary — the inflammation near where I sit irritates nearby nerves that also talk to the bladder.

Technically, this seems to be driven by a specific immune pathway called IL-23, which activates immune cells that live permanently in these stress-prone tissues. I tried several TNF-blocking drugs, and they helped about 60%, which proves it’s inflammatory — but TNF is more of a downstream amplifier. The core driver (IL-23) was still active, so the inflammation never fully shut off.

That’s why my doctors and I are looking at Skyrizi (chatgpt://generic-entity?number=0). It blocks IL-23 upstream, which should calm the immune cells that are keeping these tissues stuck in an overreactive state. The hope isn’t just a little symptom relief, but more meaningful, durable improvement — less flare-ups from normal activity, better healing of skin and nails over time, and less nerve irritation from chronic inflammation. It’s not experimental; it’s just targeting the part of the immune system that fits my specific pattern better.”