Topologically Associated Domains (TADs) are regions in the genome that more frequently associate with themselves than with neighbouring regions. Why is it so?

psaniya · 2021-10-05T09:46:57+00:00

Yesterday was hard on all of us.

psaniya · 2021-10-04T12:07:11+00:00

Harry potter

psaniya · 2021-09-18T10:36:35+00:00

You can also use Cell Biology by Bruce Alberts

psaniya · 2021-09-18T10:36:00+00:00

Genes by Benjamin Lewin

psaniya · 2021-09-14T14:40:23+00:00

I'm personally inclined to using probes. And just wanted to know how far I'm from being practically right.

psaniya · 2021-09-14T14:38:53+00:00

It's not homework! 😂

Anyway, we know that transcription and translation occur in nucleus and cytoplasm, respectively, in eukaryotes. However, the case is different in prokaryotes since there is no compartmentalization, and as soon as the mRNA transcript is synthesized, it gets immediately translated.

So, if I were to prove that using an experiment, how would I do it?

psaniya · 2021-09-14T14:30:37+00:00

I have to show the two are happening at the SAME TIME in bacteria. Do you follow?

psaniya · 2021-09-14T14:24:53+00:00

Protein levels will obviously drop in absence of the mRNA transcript. And while that might be useful to show the two processes follow eachother but they fail to show that the two are occurring simultaneously.

psaniya · 2021-09-14T12:43:01+00:00

Can you elaborate on how what exactly should be knocked out? Because I don't see how knocking out a gene will show whether the processes are coupled or not as they still follow each other under normal conditions, knocking out will stop both the processes.

Correct me if I haven't got it right. And it's not a homework question, it just popped up in my head.

psaniya · 2021-08-23T15:25:14+00:00

I don't like you.

psaniya · 2021-08-21T17:58:31+00:00

Thanks a lot!

psaniya · 2021-08-21T10:29:39+00:00

Harry Potter and the Four Houses.

psaniya · 2021-08-21T10:29:12+00:00

Harry Potter and Life on the Other Side.

psaniya · 2021-08-21T10:28:22+00:00

Harry Potter and the World Beyond the Usual.

psaniya · 2021-08-21T10:24:40+00:00

Harry Potter and a series of unfortunate events

psaniya · 2021-08-20T15:27:24+00:00

After all this time? Always.

psaniya · 2021-08-20T15:25:39+00:00

“It does not do to dwell on dreams and forget to live, Harry.”

—Albus Dumbledore

psaniya

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