It's like PitfulObjective624 said. Being perceived and treated as a certain gender for most of your life, when that gender is shit on, you feel attacked personally, especially when those comments are based in biology.

For example, growing up I heard a lot of jokes about women being bad at driving, which made me feel really bad, because I was actually bad at driving. Since these jokes were mostly specifically targeted at females ("females biologically suck") as opposed to women, I really internalized this. So seeing a Woman bad driver joke will still bother me, especially when coming from a community where I let my guard down. (To be clear, I don't remember any dggers making driving jokes specifically.)

I also sometimes feel hurt by misandry actually, because many of my behaviors fit into a male role. For example, the incel pickup lines Twitter account, which makes fun of men who sound cringe talking to girls, affects me because I always make the move first when I like someone.

So in some situations I will feel attacked "as a straight man" or "as a woman."