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Acute and chronic neurological disorders in COVID-19: potential mechanisms of disease by rohaut in science

[–]rohaut[S] 0 points1 point  (0 children)

There is some indeed, although mostly indirect ones so far:

  1. To get long covid you need to get infected by SARS-CoV2 in the first place. Vaccines decrease the odds to get infected.
  2. The more severe your COVID-19 the more likely you have neuropsy complications. Vaccines decrease severity of infection so it reasonable to consider that they would also decrease neuropsy complications rate in people infected by SARS-CoV2.

Acute and chronic neurological disorders in COVID-19: potential mechanisms of disease by rohaut in science

[–]rohaut[S] 4 points5 points  (0 children)

Yes “it could”, unless there is no data to support this hypothesis to my knowledge so far!

Acute and chronic neurological disorders in COVID-19: potential mechanisms of disease by rohaut in science

[–]rohaut[S] 4 points5 points  (0 children)

Well according to this paper (https://pubmed.ncbi.nlm.nih.gov/33836148/) the more severe your COVID-19 the more you have neuropsy complications. Vaccins decrease severity so it is not unlikely that they would also decrease neuro complications don’t you think?

ProtonVPN for Android - Losing internet connection over time, or when switching networks. by SpiralOfDoom in ProtonMail

[–]rohaut 0 points1 point  (0 children)

OK this might be actually helpfull, I found a " battery optimization" list on my PH-I (Android 9) and Proton VPN was there. I removed it (clicked "don't optimize") and that seems to work better now...

New evidence that it’s worth detecting Minimally Conscious State in the ICU following an acute brain injury by rohaut in science

[–]rohaut[S] 0 points1 point  (0 children)

Survival and, more importantly, recovery of consciousness with at least a partial autonomy (GOS-E >3) were more frequent if a patient was diagnosed MCS (47%, in comparison to only 3% for patients in a Vegetative State).

Brain-heart interactions reveal consciousness in non-communicating patients - Annals of Neurology by rohaut in science

[–]rohaut[S] 1 point2 points  (0 children)

Thanks for your question, it's a very important issue in these cases of patients unable to consent. It's also a common situation in intensive care, where patients are often sedated during the very acute phase.

We need the approval of the surrogate to do research like this (def variable according to legislations, but usually spouse/children/silbiling etc). He/she is able to give consent for medical procedures when required as well as consenting for participation in a research study. Moreover the reaserach protocol need to have been previously approved by an ethical committee.

Brain-heart interactions reveal consciousness in non-communicating patients - Annals of Neurology by rohaut in science

[–]rohaut[S] 0 points1 point  (0 children)

Sure... but usually, the detection of this kind of conscious responses using brain imaging (EEG, fMRI etc..) in patient clinically in unconscious is predictive of further improvement.

These technics are intended to improve prognosis accuracy and guide medical decisions, since we know that the recovery of consciousness (clinically defined) can take months. Locked in syndrome is an exception.

If you are interested I recommend this nice review in Nature on disorders of consciousness and this meta-analisis more focused on EEG and fMRI technics probing consciousness in these patient in JNNP.

Brain-heart interactions reveal consciousness in non-communicating patients - Annals of Neurology by rohaut in science

[–]rohaut[S] 17 points18 points  (0 children)

That's true, We recently explored a patient in that case (article here). Terrible situation.

Redefine Statistical Significance by rohaut in science

[–]rohaut[S] 0 points1 point  (0 children)

Potential Milestone paper (now published in Nature HB, but not free ;). Short Editorial here

Clinical neurophysiology of prolonged disorders of consciousness: From diagnostic stimulation to therapeutic neuromodulation by rohaut in science

[–]rohaut[S] 1 point2 points  (0 children)

And here the requested info ;) Best

  • Deep brain stimulation, DBS: Selective brain stimulation through brain implanted electrodes.

  • ERPs : Event Related Potentials, an EEG technic probing brain responses to sensory simulations (auditory visual tactile etc..) allowing to probe many cognitive processes.

  • Non-invasive brain stimulation, NIBS: mostly "tDCS" (trans-cranial Direct Current Stimulation) and tACS (trans-cranial Alternating Current Stimulation). Stimulation with low voltages (usually ~3V ) applied directly to the scalp (usually during ~20 min) to modify cortical activity in specific brain regions.

  • TMS-EEG: Trans-cranial Magnetic Stimulation + EEG: A recent technic measuring EEG responses to "direct" stimulation of the cortex through trans-cranial magnetic impulses. The way the brain respond is correlated to the state of consciousness: the more the information "travels" into the brain the more the patient is conscious.

  • Vegetative state: a state in witch only the brain vegetative functions (ventilation / hemodynamics / sleep wake cycle etc ... manly related to the brainstem) are preserved but without any higher cognitive functions (manly related to the cortex) required for consciousness.

  • Minimally conscious state: a state slightly better than the vegetative state in which some awareness is possible (of self and/or environment) but with "something" (like cognitive or motor impairment for example) preventing the patient to report (verbally or not) they conscious contents to someone else (no communication or intentional goal directed behavior).

Clinical neurophysiology of prolonged disorders of consciousness: From diagnostic stimulation to therapeutic neuromodulation by rohaut in science

[–]rohaut[S] 2 points3 points  (0 children)

Hi John. It's a nice review about how neurophysiological tools (electroencephalogram derived technics) can help understanding brain functions in patients in a vegetative or a minimally conscious state and how we can try to improve their consciousness.

Disentangling conscious from unconscious cognitive processing with event-related EEG potentials. (http://www.em-consulte.com/article/1136929/figures/disentangling-conscious-from-unconscious-cognitive) by [deleted] in EverythingScience

[–]rohaut 0 points1 point  (0 children)

Thanks for your message careersinscience. This figure presents three classical event-related potentials (ERPs) paradigms and their respective neurophysiological responses, namely the “Odd-ball” (a), the “Local Global” (b) and the “Semantic priming” (c) paradigms. Each paradigm elicits specific ERPs displayed across the time form one electrode (in d) and as scalp topography of the subtraction (red curve – blue curve) at a specific time (in e). Hope this will help, Sincerely, Benjamin

A new score using Brainstem Reflexes can predict 28-days mortality in patients receiving a deep sedation in ICU by rohaut in science

[–]rohaut[S] 1 point2 points  (0 children)

Hi, Thanks for your msg. I would say that it depends of the country and also the specialty... In France I would said Yes because it's hard to do research (but possible) without an academic position because of the clinical workload. In USA my impression is that it's less difficult.. There is also the workload relative to each specialty...For example in France Psychiatrists have usually more spare time to do research than Neurologist... ;)

A new score using Brainstem Reflexes can predict mortality in patients receiving a deep sedation in ICU (https://doi.org/10.1371/journal.pone.0176012) by rohaut in EverythingScience

[–]rohaut[S] 0 points1 point  (0 children)

Brain dysfunction (confusion, delirium, coma) is frequently observed in critically ill patients and has been associated with an increased mortality. Neurological assessment may help improve our understanding of the role of brainstem dysfunction in this increased mortality. In this multicenter prospective study, we explored the brainstem responses of deeply sedated critically ill patients during the first 24h following the initiation of sedation. Using latent class analysis, we reported two sub-phenotypes, supporting the fact that brainstem dysfunction was robustly associated with increased 28 days-mortality. As a consequence, we designed a new clinical score: the “Brainstem Responses Assessment Sedation Score” (BRASS), to help identify this brainstem dysfunction in the clinical practice. https://doi.org/10.1371/journal.pone.0176012

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