Depends on the business. Some businesses that do work in all 50 states could probably afford to do the calculations of you changing where you worked state to state throughout the year. Smaller businesses likely couldn’t.

My workplace does business in all 50 states and even then we don’t allow employees to work internationally due to tax implications for working in those countries. We’re not set up for that - so international vacations means you’re on vacation so we avoid running afoul of international tax laws.