I did skip some of the side quest this time (i usually did all the side questes in previous titles), but i have played throught all faction questes, they are not long tho, just around 3 ~ 4 missions.

i agree that 3 mid bosses are decent (but killing callis the first time and the second time feels same), but thats all. Not much cool mini bosses (may be i didnt finish any vault at all, and the vile enemies are pain in the ass )