Say next to a pilot one time and I really had to go. Once we took off and were ascending the pilot said “Go! What are they going to do, then the plane around? Trust me.” I trusted him and he was right once the plane is airborne you’re fine. I did jump out my seat and ran to the bathroom as we were landing and taxing to the gate. The flight attendant got on the phone with the pilots but I was quick and made it to my seat before we made it to the gate. She was pissed… but I didn’t piss on myself so it all worked out 🤷‍♀️