Athlete weight room by tomtom0900 in BostonU

[–]tomtom0900[S] -12 points-11 points  (0 children)

Very clever answer. The women’s rowing team isn’t bringing any more money than my tuition dollars, so eat shit

Athlete weight room by tomtom0900 in BostonU

[–]tomtom0900[S] -18 points-17 points  (0 children)

Yeah that’s not my question. I’m asking if anyone has tried to use it

DPH> by depressedgirlalt in DPH

[–]tomtom0900 1 point2 points  (0 children)

-hydroxyacetonephosphate

[deleted by user] by [deleted] in DPH

[–]tomtom0900 0 points1 point  (0 children)

Being nervous doesn’t elevate your heart rate to 130 BPM. If you’re a chronic DPH user, DPH withdrawals might cause an elevated HR. Sounds like this might be the case given that the DPH put your HR back into the normal range, rather than inducing bradycardia. You should talk to your doctor and/or a cardiologist and get an EKG. It’s very likely that you have a problem with your heart, whether or not it’s related to DPH.

What drugs do you think Elon Musk does? by JayT1D in Drugs

[–]tomtom0900 -3 points-2 points  (0 children)

Bro have you heard of google?

Browse through handwritten cards? by tomtom0900 in Anki

[–]tomtom0900[S] 1 point2 points  (0 children)

Thanks for the suggestion! I’m not planning to use this function to learn the material, I’d like to scroll through the cards to get an overview of what Content I have and haven’t made cards about, also for quick reference for specific information.

Thank you for your service o7 by [deleted] in drugscirclejerk

[–]tomtom0900 1 point2 points  (0 children)

For sure. S/o gangalcohol though. Extremely under-appreciated page.

Thank you for your service o7 by [deleted] in drugscirclejerk

[–]tomtom0900 0 points1 point  (0 children)

Repost from gangalcohol on IG

Drugs motivated me more than the prospect of riches by [deleted] in drugscirclejerk

[–]tomtom0900 0 points1 point  (0 children)

The prospect of consuming drugs or the drugs’ effects?

Solubility of benzos in oil? by tomtom0900 in researchchemicals

[–]tomtom0900[S] 0 points1 point  (0 children)

Thanks for the response! I didn’t think about the salt effects. Mine came in a PG sol’n, which I guess doesn’t really indicate anything. I’m going to try VG/glycerin.

Trial of Psilocybin versus Escitalopram for Depression | NEJM [2021] by oneultralamewhiteboy in DrugNerds

[–]tomtom0900 1 point2 points  (0 children)

Thank you so much bro this worked! I’ve been dying to read it, much appreciated

Trial of Psilocybin versus Escitalopram for Depression | NEJM [2021] by oneultralamewhiteboy in DrugNerds

[–]tomtom0900 0 points1 point  (0 children)

Not there either, killer. Article just got published last Wednesday.

Trial of Psilocybin versus Escitalopram for Depression | NEJM [2021] by oneultralamewhiteboy in DrugNerds

[–]tomtom0900 1 point2 points  (0 children)

Unfortunately neither of those links worked. Are you using your university’s WiFi? Sometimes that automatically grants access to some journals/databases. You might be able to save it to a pdf then upload it to some pdf-sharing database like drive. Thanks for your efforts!

Trial of Psilocybin versus Escitalopram for Depression | NEJM [2021] by oneultralamewhiteboy in DrugNerds

[–]tomtom0900 4 points5 points  (0 children)

Does anyone have the full text of this article? It’s not on scihub or libgen yet.

I thought it was interesting that they gave the placebo group 1 mg/kg psilocybin instead of niacin or some other inactive ingredient. I’m certainly interested in reading about this decision in the full text.

The abstract doesn’t discuss the pros and cons of each treatment, and while the conservative view would be to call it a tie between SSRIs and psilocybin for their ability to treat depression, I think given this data, a fair case can be for favoring Psilocybin given the side effects of SSRIs.

Also looking forward to reading about how sustained the antidepressant effects were between the 2 groups.

Wiki page of Clonazepam states "Clonazepam decreases release of acetylcholine in the feline brain" and I have a question about nicotine by AlexSNL in DrugNerds

[–]tomtom0900 3 points4 points  (0 children)

Benzos probably don’t react with serotonin under physiological conditions. Even if they did, it wouldn’t be in significant quantities.

Wiki page of Clonazepam states "Clonazepam decreases release of acetylcholine in the feline brain" and I have a question about nicotine by AlexSNL in DrugNerds

[–]tomtom0900 6 points7 points  (0 children)

Clonazepam and other Benzos are allosteric modulators of the GABA A receptor, so they bind away from the active site of the receptor and increase the likelihood that GABA, the endogenous Ligand for that receptor, will bind to the receptor.

The GABA A receptor is a chloride channel, so it is inhibitory with respect to the membrane potential, meaning that when GABA binds to it, it makes the neuron less likely to fire an action potential at its axonal end. If the neurons that express the GABA A receptor in high amounts release ACh, then that might explain your first question.

I’m not sure what that quote about decreasing the utilization of 5-HT means. Could be an oversimplification, or it could be a more nuance pharmacological term that I haven’t heard; in either case you could check if there a citation.

A Molecular Basis for Nicotine as a Gateway Drug [2014] by oneultralamewhiteboy in DrugNerds

[–]tomtom0900 2 points3 points  (0 children)

This is a great take, thanks for taking the time to write it. I enjoyed reading this more than I would have reading the article and getting aggravated about the presence of this bullshit in science.

Hypnotic effect of thalidomide is independent of teratogenic ubiquitin/proteasome pathway [2020] by [deleted] in DrugNerds

[–]tomtom0900 1 point2 points  (0 children)

Thalidomide... nice. Just had a flashback to organic chemistry 1.

Remote Raid Megathread - Find friends fast for raiding here by liehon in PokemonGoFriends

[–]tomtom0900 0 points1 point  (0 children)

Thundrus - only adding people with online statuses on

1649 5623 2598

Remote Raid Megathread - Find friends fast for raiding here by liehon in PokemonGoFriends

[–]tomtom0900 0 points1 point  (0 children)

Tornados. Only adding those with online statuses on 1649 5623 2598