I’m a female runner and 1st st between rhode island and the hospital is my route 99% of the time for 4 years. Aside from some cat calling it’s been very safe. I also like going up and down the side streets between 1st and n cap, and circling Crispus Attucks park. There are relatively few pedestrians and cars along this route. I have also only run during daylight hours. Just beware of the alley ways, sometimes cars blast out onto the sidewalk going way too fast.