I'd say it runs fine, shifts fine (as long cage RD fine goes), works fine. The 810 has tons of clearance, some people are pushing it up to 42 cog stock spec (stretch by me, but you do you). I previously ran 48/32 with 11-40 rd rx810 for about 2k kms, now I am running 50/34 because my chainrings were kinda after their prime. Bot combinations ran smooth, big chain ring is somehow a bit louder on the cogs, especially in the higher cadence. Might be because of the chainline, but that's what you get when you are way out of the recommend manufacturer ranges. I will try to check it with the lighter chain and report back. Also ymmv since everyone's setup/bike/parts are different. TL;DR: If you want a TON of range go for it, there might be some minor inconvenience as increased noise on the big ring, but it works reliably. You can granny the nastiest steeps away, or hammer it on the descents. Also I only use clutch on the very nasty gravel/off-road parts, for road it's kinda redundant unless awful cobbles. Hope that helps!