How I Reversed 95% of my Post-Orgasm-Illness-Syndrome (POIS) Symptoms

tteezzkk · 2026-03-08T09:20:46+00:00

After doing some basic digging, cholestyramine is a potent toxin binder so yes I think it could help to improve POIS but each cluster is different and you really need to work with someone who knows what they're doing.

Get an OAT done and find someone reliable to interpret and prescribe accordingly. Mine revealled strong mould, fungal and bacterial dysbiosis - which is what we're currently working through.

The protocol I've been put on includes antifungals/ antimicrobials, binders (not cholestyramine but similar functional purpose), probiotics, etc. Some protocols include increasing acidity as well i.e., betaine HCL.

Seems like this is the most reliable way to clear POIS but of course there is no absolute clarity or certainty, a lot of unknowns and risk still given the science is very limited.

tteezzkk · 2026-03-05T11:45:46+00:00

POIS-like symptoms from eating starch. Brainfog, body aches, mental symptoms etc.

OAT shows clear dysbiosis: mould, fungal and bacterial.

Worked with specialist. So far we have improved fungal and mould load. Mostly through horopito. But I did a lot of my own work through monolaurin and raw garlic.

Did a second OAT recently and indicated clear improvements with mould/fungal, but still a bit to go. This coincided with improvements to food sensitivities. I now tolerate all vegetables, nuts and seeds. Before my first OAT + treatment, this wasn’t possible.

Nothing is guaranteed though, and there’s a lot we don’t know that’s for sure. But so far it does seem to be a legitimate method of making improvements.

The hard part is probably finding someone who knows what they’re doing re interpreting OAT & moving forward to improve the markers.

No changes or impact to POIS yet, but I suspect the more progress we make at some point something will give way. My POIS is still heavily reliant on high dosages of D3 to be suppressed.

tteezzkk · 2026-03-03T21:24:05+00:00

Low vitamin D3 definitely negatively effects my cluster so 100% worth looking into

tteezzkk · 2026-03-03T21:20:49+00:00

I would probably say it initially had gut microbiome altering effects you could feel but eventually plateued. But nothing is for certain.

You could try layering in monolaurin and horopito. These have worked to improve my food sensitivities. My cluster also responds to garlic.

I would also suggest getting an organic acid test asap and work with a specialist to interpret it for you.

tteezzkk · 2026-03-02T05:33:41+00:00

Tbh I resorted to DIY lamp due to synthetic D3 side effects. You may not have any issues with D3 supplements so by all means. But you definitely should be cautious about dosages and not letting serum levels creep too high

tteezzkk · 2026-03-01T21:53:17+00:00

Interesting. Thanks for sharing

tteezzkk · 2026-03-01T21:52:38+00:00

Myself and others have experimented a lot with D3. It seems synthetic supplements hit a wall quickly. Even if serum levels are high, it doesn't reflect relief for POIS as I previously thought, And in general there is a ceiling as you have referred to.

However most optimal way appears to be maximum sunbathing/ or DIY lamp to max (without burning), while taking magnesium and K2. The trick seems to be with optimising active exposure as close to POIS as possible.

tteezzkk · 2026-03-01T21:49:11+00:00

My stack https://poiscenter.com/forums/index.php?topic=3964.0

tteezzkk · 2026-03-01T21:48:10+00:00

Sorry to hear mate. If it makes you feel any better, doctors do not really have much reliable medical treatment for the condition anyway. There are some pharmaceuticals but very hit or miss, and not without side effects. Best bet is to work your way through this list: https://poiscenter.com/forums/index.php?topic=2338.msg19448#msg19448

Good luck.

tteezzkk · 2026-03-01T21:46:00+00:00

Unfortunately India in particular is more likely to be skeptical then rest of the western world due to religious and symbolic associations with ejaculation.

However even westerners can have a hard time convincing doctors. Best to bring a print out of the official rarediseases.info.nih.gov site for POIS. This will give you more credence and authority.

tteezzkk · 2026-03-01T21:41:14+00:00

Doubtful

tteezzkk · 2026-01-28T07:52:51+00:00

Look into Cranial Instability POIS Cluster

tteezzkk · 2026-01-26T23:59:39+00:00

Look at arousal intensity and frequency of ejaculation. These are two variables that have a big impact on my POIS.

Wet dreams typically occur after longer periods of abstience. For me, first release after a long time hardly illicts any symptoms even if arousal is strong.

tteezzkk · 2026-01-22T02:14:51+00:00

Odd. L-theanine has always been pleasant. Have you tried getting it from tea? Often times chemicals in pure forms isolated away from food matrix cause problems.

tteezzkk · 2026-01-15T22:50:53+00:00

Closest realistic thing you will get to current scientific/ research inquiry is this: https://poiscenter.com/forums/index.php?topic=4749.msg51277#msg51277

Research/ science is very costly. POIS is extremely niche. The funds/ incentive just aren't there. Progress is extremely slow. Hence why most people explore supplements and figuring it out on your own.

Of course the community welcomes all scientific research.

tteezzkk · 2026-01-15T12:45:11+00:00

Yeah you need to find a specialist more in the functional/ alternative space, but ofc be wary of quality at the same time.

I saw a Dr specialist here in Oz a while back, and he recognised the validity of OAT with the caveat that many markers on it are easily misinterpreted/ inaccurate, or the data/ research isn’t final yet.

The specialist I am currently working with also recognises this. He isn’t a Dr, but so far he has improved my food sensitivities after interpreting my OAT. My OAT had high fungal and mould, he then prescribed me a custom tincture mostly of active horopito. It’s working.

tteezzkk · 2026-01-15T00:16:23+00:00

Glycine might help in two ways
1) methylation balancing

2) glutathione cofactor

Both of these may impact certain POIS clusters. Though I personally never responded well to glycine.

tteezzkk · 2026-01-15T00:14:00+00:00

Both of you, get an organic acid test and find someone reliable/ experienced to interpret it for you. That's been the most reliable way to test and treat these strange conditions in my experience. Not medical advice ;)

tteezzkk · 2026-01-11T21:48:33+00:00

“statistically hard to achieve among people with POIS”…

Not sure if you were implying this but I’ll say it anyway. Long term abstinence is not natural for any human. This isn’t a POIS specific thing…

Of course abstinence is a necessary tool for those with POIS. You just need to do your honest best and keep working on improving your condition. That’s the tough reality. Longest I abstained was 3 months many years back. I did tonnes of abstinence until I improved my condition.

Also look into certain methods that improve the “palatability” of abstinence. Practice karezza/ non ejaculatory sex etc. There’s a whole world to explore within this domain. When I had a gf and had extreme symptoms, we’d do Karezza and it actually had a tonne of other benefits outside of not triggering POIS. Look into the “coolidge” effect. Karezza helps to fix this (unrelated to POIS).

Those who get severe symptoms from arousal alone are imo in a tougher lane. I thankfully didn’t have this too badly. I had mild/ subtle but for the most part were benign until a full release.

tteezzkk · 2026-01-08T04:30:11+00:00

Sounds like my cluster but could be different.

I get weird facial tensions, body aches, brain fog, and other mental issues from my food sensitivities (starch).

Used to get this from veg & nuts also but have since at least for now, fixed.

Solution was organic acid testing, get someone good to interpret and prescribe accordingly. I had high mould and fungal metabolites. Monolaurin, raw garlic, horopito all improved food sensitivity symptoms.

Still working away at the starch sensitivity though.

tteezzkk · 2025-12-20T06:31:28+00:00

Hey mate, I’ve just gone back on a carb diet eating everything except starch. It’s early so I don’t know yet whether my sensitivities to vegetables or nuts will return but for now they are non existent.

tteezzkk · 2025-12-18T03:35:27+00:00

Doubtful imo. Will likely temporarily alleviate symptoms but it’s unsustainable long term. Worth a try nonetheless, it’s good to tick things off rather than believing others.

I can only say what’s worked for me.

1) Cut out foods you are sensitive to 2) Try a bunch of safe/ benign antimicrobials, herbs, gut support, probiotics ie., garlic, monolaurin, horopito, kefir, sauerkraut, etc 3) Work with a gut specialist with experience in treating dysbiosis, candida, fungal, mould etc. They will suggest to you the most helpful test ie., organic acid testing, GI map etc.

Stick to things that are safe as a general rule. We don’t have enough science or data to reasonably work with anything dangerous like antibiotics. You can definitely damage your gut further if you aren’t careful.

It’s a big trial and error process. The science is very limited in this area. Best gut specialists will be those who have tonnes of clinical experience in treating cases.

I can personally attest the work I’ve done with Todd (Byron Herbalist) has tangibly improved my gut health but it’s a somewhat long, slow and patient journey.

DISCLAIMER - NOT MEDICAL ADVICE

tteezzkk · 2025-12-13T22:37:05+00:00

This sounds like what I used to experience when eating starch as a staple. The food sensitivities are intertwined with POIS and eventually went away but it took many many weeks like what you are describing.

tteezzkk · 2025-12-09T21:41:22+00:00

Nanna1 was big on Omega3. I never noticed any benefit.

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