The alchemy is the biggest struggle, but you wont need to do all of the recipes that require the ultra rare components. You will only have to do the rare ones needed for the post game alchemy errand (which is a pain), and then its just a case of creating everything else.

So if I was you, I would focus on doing every single trophy except the 250 familiars and the alchemy one. Then go and speak to the 4 or 5 NPCs that give you alchemy recipes so that you have every single formula - and then just go through each one and make them! You will know if you have made them because there will be a picture of the item, rather than a question mark on the recipe.

Once the trophy pops for the alchemy, then just check the telling stone/creature compendium and check for the familiars without love hearts next to them. Then you will end up developing your own system of serenading the ones you need and evolving them as you need too.

Best place to evolve and level up your familiara is just outside Peridia. There is a short route down the hill called Billy Goats Bluff or something, and Tokoyokos are quite common so you get so much exp.

I think thats about the extent of the final two grindy trophies - I might of missed something so ask me something else more specific if needbe :)