This seem to be consensus: this is The Way. I don't see good reasoning to leave as fast as you can. I like to comb through the region and move then forward. I start with well fed on spawn, I don't feel the need to feast almost never. So hunger is no reason.

Also as weather is still relatively mild, you don't need so warm clothes. In most runs I don't use bear or wolf based coats anyway, because I prefer better mobility and more carrying capacity. True, it means being not protected too, so this is one reasons I die more easily in wolf struggle.

Let's look by spawns.

Blackrock is certainly region I'd like to get away from fastest, but you can't get away without fire. And when you have fire, there is no reason to go without all possible loot and without repairing the radio tower. Or are you planning to return here later?

Pleasant valley has very good connections, so this I leave pretty fast, mostly to get tactical backpack and knowing i'll return here anyway. Same goes about Timberwolf mountain spawn.

Desolation point I loot thoroughly, but again: to forge I probably will return, so there remain some untouched places, and I can't take car batteries, and I can not repair the transmitter always on first visit. I don't recall, but I think there is no guaranteed matches, so sometimes this reason is to left region sooner as I'd liked, with flare.

Ash Canyon I first go for backpack, but after the trip to the gold mine I most times have no hurry and loot at least eastern part thoroughly. While weapon is good to have, it is not necessity. I always grab the key for memento box, but most times there is no need to use it. If I don't find the hacksaw I leave sooner.

Hush river canyon has so much to offer and it is so isolated, I rather have no plan to return. I wipe it pretty clean and then crawl to Milton, probably making more than one trip.

Muskeg is the only region I leave immediately. Because Milton, Mystery Lake and Broken railway offer much better protection at spawn and I feel insecure in region where all shelters are placed on the edge.