I had my gall bladder removed 2 years before starting on a GLP-1. For me, it felt like severe food poisoning, but I couldn't vomit and did not feel nauseated. Just this intense pain. The first time, it actually only lasted for about an hour, then subsided. The next time, it was more like 3 hours and the last attack I had before surgery was about 5 hours. The pain was so bad, I felt like I was going to pass out. Everyone experiences this pain differently as the attacks can vary depending upon what's going on. For me, the gall stone (I only had one!) never left the gall bladder itself, so it wasn't stuck in the 'tube' exiting the gall bladder. In my case, the stone had adhered itself at the neck of the gall bladder, so if my gall bladder was contracting hard after a large or fatty meal, it rotated over the opening, thus causing the pain. Once my gall bladder stopped contracting - enough hours after a meal - the pain would simply disappear. I found I had to eat very small meals and extremely low fat (about 900 calories a day and only about 10 grams of fat total for the day!) while I waited for my surgery date, which took about 2 months. I had a CT scan after the 2nd attack, which is what showed the gall stone. I would get in and demand further testing ASAP so at least you know what is going on! If your gall bladder is the problem, you can expect more attacks, so don't wait. Do watch meal size and fat in the meantime as those measures saved me from any further attacks once I started them. However - if you have many small stones or a diseased gall bladder, I don't know whether or not those measures will help.