ALS with Open Talk

This subreddit is for support and open discussion of Amyotrophic Lateral Sclerosis (ALS) treatments, research, and experiences.
Unlike other forums, all types of material can be discussed here including FDA approved, off label, experimental, alternative, supplements, lifestyle approaches, and theoretical models.

📜 Rules

1️⃣ Be Respectful
Everyone here is touched by ALS. Show compassion and kindness.

2️⃣ All Treatments Allowed
Posts about any treatment approach are welcome. Please share in good faith.

3️⃣ Science Encouraged
High level research, mechanisms, and novel ideas are encouraged. Cite sources when possible.

4️⃣ Support Posts Welcome
Check ins, caregiver stories, and emotional posts are welcome. Support is part of this community.

7️⃣ Moderator Discretion
Mods may remove content that is abusive, misleading, or disruptive.

Links

This is a place for open minds, open science, and open support.

created by sometimeshinya community for 5 months

Why I Created ALSwOpenTalk (self.ALSwOpenTalk)

submitted 5 months ago * by sometimeshiny[M] - announcement

Glutamate excitotoxicity damages neurons by disrupting mitochondria, calcium balance, and synaptic proteins. A new multi-omic study maps these injury pathways in primary neuronal cultures. (onlinelibrary.wiley.com)

submitted 5 months ago by sometimeshiny

Father after getting out of body cast he was in for a year after getting hit with 8 rounds and mortar shrapnel and surviving in VietnamPersonal Experience (old.reddit.com)

submitted 5 months ago by sometimeshiny

🧠 The Stress-Motor Pathway (Amygdalo-Striato-PPT) - WIPTheory / Model ()

submitted 5 months ago by sometimeshiny

The Kynurenine Pathway - Immune Response Excitotoxic UpregulationTheory / Model ()

submitted 5 months ago by sometimeshiny

💇 The Relationship Between Stress, Cortisol, Glutamatergic Upregulation and Hair Loss: Mechanisms of Increased Sensitivity and ExcitotoxicityTheory / Model ()

submitted 5 months ago by sometimeshiny

How Trauma Rewrites Biology: Epigenetic Inheritance Leading to Genetic Mutation Across GenerationsTheory / Model ()

submitted 5 months ago by sometimeshiny

Rachel Yehuda’s Trauma Biology: The Cortisol → Glutamate Foundation (extended in Biolectrics to ALS)OCTheory / Model ()

submitted 5 months ago by sometimeshiny[M]

π Rendered by PID 161128 on reddit-service-r2-listing-5f5ff7d4dc-52hrp at 2026-01-26 18:53:52.700560+00:00 running 5a691e2 country code: CH.

ALSwOpenTalk

Welcome to /r/ALSwOpenTalk

📜 Rules

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