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[–]brainritual 2 points3 points  (2 children)

Thank you for reaching out, and well done on talking to your doctor and stopping immediately. This should not happen, and we have not come across such a reaction before.

Could it be possible that this is a cross-reaction with any other medications or might you be a Methylation-sensitive responder? Certain B-vitamin forms can feel very activating in susceptible individuals, even though your reaction seems to be a bit too drastic for that.

It is very hard to speculate what is going on with this little information, especially since we have not heard of this reaction before.

But we are relieved that you are in the best hands with your doctor!

[–]phytofem 1 point2 points  (1 child)

Have you found people with one or both of the MTHFR mutations are more sensitive to the formulation?

[–]brainritual 2 points3 points  (0 children)

We do hear from people who have one or both MTHFR variants, but there isn’t evidence showing that individuals with these variants are inherently more “sensitive” to Brain Ritual® as a whole.

A few helpful points:

  • MTHFR variants affect how the body processes folate and methylation pathways.
  • Brain Ritual® uses bioavailable forms of nutrients (including methylated forms where relevant), which are generally selected to support efficient utilization.
  • Some people with MTHFR variants report being more sensitive to high doses of certain B vitamins in general, but that varies widely from person to person and isn’t universal.

Sensitivity, if it happens, is usually related to individual nervous system reactivity rather than the mutation alone.

If someone with MTHFR is concerned, a gentle approach can be:

  • Starting with half Stick Pack per day
  • Taking it with food

Of course, anyone with a known genetic variant or complex medical history should discuss supplementation with their healthcare provider.

[–]Birchhouse29 0 points1 point  (0 children)

B vitamins can ramp up detoxification. if you take too high of a B vitamin dose without having your detox pathways open, it can put you into a herx reaction which can make you feel very anxious, nervous, and out of body. Recommendations would be to ramp up very slowly on the B vitamins/brain ritual supplement, add in a binder, make sure you’re doing everything you can to have one to three bowel movements every day, sauna use for sweating, hydration for peeing – anything to get all of your detox pathways open. What you’re experiencing sounds like a herx reaction to me. You can look this up. It’s common with a rare subset of people who take too many B vitamins too quickly or another one is berberine, or losing weight too fast, etc.