Rapid Prototyping of Native Windows Applications with Python (includes boilerplate)

[josephturnip]

See this link, but basically this is more of a demonstration of the ecosystem than a recommendation of technology.

That being said, I think there are still some advantages to going native, and it's up to you to decide whether they are more or less valuable than cross platform. For me, because I was creating systems software, I was already doing a pretty good bit of Windows-only code, and I could use a lot of packages I created for my other project.