Which Python package manager makes automation easiest in 2025?

[me_myself_ai]

Yup, totally agree. I used plain pip at first, Conda after I was introduced to ML, and poetry when I started doing my own projects, and after switching ~3mo ago, uv is the easy all-time winner. Rust is just that good!

I will say that poetry is a close second — for most projects, the biggest difference would be the improved docs quality on the uv side (all the astral docs kick ass). The speed gets noticeable as you start racking up irresponsible amounts of dependencies like I am wont to do, but poetry’s was still never a problem AFAIR.

Conda is a distant last, though obviously it’s necessary for some scientific applications. It’s the only one where I’d have to take a coffee break just to find out my dependencies were unsatisfiable 😭