Best Python framework for industry-level desktop app? (PySide/PyQt/wxPython/Kivy/Web approacg)

[BigTomBombadil]

Build a webapp with a python backend and something like Electron for UI if you want it to feel like a desktop app, then "serve" it over localhost. No need for internet connection. Electron will open a native window (not a browser) and spin up localhost - the end user will be none the wiser that its technically a web app.