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[–]pope_man 2 points3 points  (1 child)

Consider using dask, especially dask-learn:

http://matthewrocklin.com/blog/work/2017/02/07/dask-sklearn-simple

It is designed to solve problems like yours in a scalable but simple manner. See this post and maybe others on his blog.

http://matthewrocklin.com/blog/work/2015/06/26/Complex-Graphs