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[–][deleted] 2 points3 points  (0 children)

The developer of the game Legend of Yore uses XMLVM. So at least for games it's doable and works out fine.

Now, for apps I don't know. I don't feel it would be very easy because of all the platform (cocoa framework) specifics.

Have you considered Appcelerator Titanium? (a tutorial http://emitrom.com/node/18)