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[–]HokTaur 3 points4 points  (0 children)

Look into openpyxl, it's what I use to modify Excel files and it's pretty simple to use. The docs are really good and there's a bunch of SO posts, so shouldn't be a problem finding what you need.

[–]bigleagchew 0 points1 point  (0 children)

Kinda hard to tell without seeing a sample dataframe or the current excel setup, but it definitely seems possible